eF-site ID 1rqc-ABCDE PDB Code 1rqc Chain A, B, C, D, E click to enlarge Title Crystals of peptide deformylase from Plasmodium falciparum with ten subunits per asymmetric unit reveal critical characteristics of the active site for drug design Classification HYDROLASE Compound formylmethionine deformylase Source Plasmodium falciparum (isolate 3D7) (Q8I372_PLAF7) Sequence A:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHSEEPLEHH B:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHSEEPLEHH C:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKA D:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHSEE E:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHSEEPL Description (1)  formylmethionine deformylase Functional site 1) chain A residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO A 301 source : AC1 2) chain A residue 156 type sequence C description BINDING SITE FOR RESIDUE CO A 301 source : AC1 3) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE CO A 301 source : AC1 4) chain A residue 202 type sequence H description BINDING SITE FOR RESIDUE CO A 301 source : AC1 5) chain B residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO B 311 source : AC2 6) chain B residue 156 type sequence C description BINDING SITE FOR RESIDUE CO B 311 source : AC2 7) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE CO B 311 source : AC2 8) chain B residue 202 type sequence H description BINDING SITE FOR RESIDUE CO B 311 source : AC2 9) chain C residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO C 321 source : AC3 10) chain C residue 156 type sequence C description BINDING SITE FOR RESIDUE CO C 321 source : AC3 11) chain C residue 198 type sequence H description BINDING SITE FOR RESIDUE CO C 321 source : AC3 12) chain C residue 202 type sequence H description BINDING SITE FOR RESIDUE CO C 321 source : AC3 13) chain D residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO D 331 source : AC4 14) chain D residue 156 type sequence C description BINDING SITE FOR RESIDUE CO D 331 source : AC4 15) chain D residue 198 type sequence H description BINDING SITE FOR RESIDUE CO D 331 source : AC4 16) chain D residue 202 type sequence H description BINDING SITE FOR RESIDUE CO D 331 source : AC4 17) chain E residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO E 341 source : AC5 18) chain E residue 156 type sequence C description BINDING SITE FOR RESIDUE CO E 341 source : AC5 19) chain E residue 198 type sequence H description BINDING SITE FOR RESIDUE CO E 341 source : AC5 20) chain E residue 202 type sequence H description BINDING SITE FOR RESIDUE CO E 341 source : AC5

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