|
eF-site ID
|
1ro9-AB |
PDB Code
|
1ro9 |
Chain
|
A, B |
|
click to enlarge
|
|
Title
|
CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP |
Classification
|
HYDROLASE |
Compound
|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Source
|
Homo sapiens (Human) (PDE4B_HUMAN) |
|
Sequence
|
A: |
SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRP
LTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV
AYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA
AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG
FKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHM
SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA
DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPM
CDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD
TLEDNRNWYQSMIPQAPA
|
B: |
SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRP
LTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV
AYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA
AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG
FKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHM
SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA
DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPM
CDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD
TLEDNRNWYQSMIPQAP
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
238 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN A 529
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
274 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN A 529
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
275 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN A 529
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
392 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN A 529
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
275 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN A 530
|
source |
: AC2
|
|
6)
|
chain |
B |
residue |
238 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN B 529
|
source |
: AC3
|
|
7)
|
chain |
B |
residue |
274 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN B 529
|
source |
: AC3
|
|
8)
|
chain |
B |
residue |
275 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN B 529
|
source |
: AC3
|
|
9)
|
chain |
B |
residue |
392 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN B 529
|
source |
: AC3
|
|
10)
|
chain |
B |
residue |
275 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN B 530
|
source |
: AC4
|
|
11)
|
chain |
A |
residue |
233 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
12)
|
chain |
A |
residue |
234 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
13)
|
chain |
A |
residue |
392 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
14)
|
chain |
A |
residue |
393 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
15)
|
chain |
A |
residue |
395 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
16)
|
chain |
A |
residue |
403 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
17)
|
chain |
A |
residue |
414 |
type |
|
sequence |
F
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
18)
|
chain |
A |
residue |
443 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
19)
|
chain |
A |
residue |
446 |
type |
|
sequence |
F
|
description |
BINDING SITE FOR RESIDUE 8BR A 531
|
source |
: AC5
|
|
20)
|
chain |
B |
residue |
233 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
21)
|
chain |
B |
residue |
234 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
22)
|
chain |
B |
residue |
238 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
23)
|
chain |
B |
residue |
347 |
type |
|
sequence |
M
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
24)
|
chain |
B |
residue |
392 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
25)
|
chain |
B |
residue |
395 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
26)
|
chain |
B |
residue |
403 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
27)
|
chain |
B |
residue |
410 |
type |
|
sequence |
I
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
28)
|
chain |
B |
residue |
414 |
type |
|
sequence |
F
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
29)
|
chain |
B |
residue |
443 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
30)
|
chain |
B |
residue |
446 |
type |
|
sequence |
F
|
description |
BINDING SITE FOR RESIDUE 8BR B 531
|
source |
: AC6
|
|
31)
|
chain |
A |
residue |
274-285 |
type |
prosite |
sequence |
HDVDHPGVSNQF
|
description |
PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF
|
source |
prosite : PS00126
|
|
32)
|
chain |
A |
residue |
234 |
type |
ACT_SITE |
sequence |
H
|
description |
Proton donor => ECO:0000305|PubMed:15003452, ECO:0007744|PDB:1ROR
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
33)
|
chain |
B |
residue |
234 |
type |
ACT_SITE |
sequence |
H
|
description |
Proton donor => ECO:0000305|PubMed:15003452, ECO:0007744|PDB:1ROR
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
34)
|
chain |
A |
residue |
234 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
35)
|
chain |
A |
residue |
443 |
type |
BINDING |
sequence |
Q
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
36)
|
chain |
B |
residue |
234 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
37)
|
chain |
B |
residue |
443 |
type |
BINDING |
sequence |
Q
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
38)
|
chain |
A |
residue |
238 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
39)
|
chain |
B |
residue |
238 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
40)
|
chain |
A |
residue |
274 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
41)
|
chain |
B |
residue |
274 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
42)
|
chain |
A |
residue |
275 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0007744|PDB:1ROR
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
43)
|
chain |
B |
residue |
275 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0007744|PDB:1ROR
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
44)
|
chain |
A |
residue |
392 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
45)
|
chain |
B |
residue |
392 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
46)
|
chain |
A |
residue |
446 |
type |
BINDING |
sequence |
F
|
description |
BINDING => ECO:0000305|PubMed:15003452, ECO:0000305|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
47)
|
chain |
B |
residue |
446 |
type |
BINDING |
sequence |
F
|
description |
BINDING => ECO:0000305|PubMed:15003452, ECO:0000305|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
48)
|
chain |
A |
residue |
487 |
type |
MOD_RES |
sequence |
A
|
description |
Phosphoserine => ECO:0000250|UniProtKB:P14646
|
source |
Swiss-Prot : SWS_FT_FI8
|
|
49)
|
chain |
A |
residue |
489 |
type |
MOD_RES |
sequence |
A
|
description |
Phosphoserine => ECO:0000250|UniProtKB:P14646
|
source |
Swiss-Prot : SWS_FT_FI8
|
|
50)
|
chain |
B |
residue |
487 |
type |
MOD_RES |
sequence |
A
|
description |
Phosphoserine => ECO:0000250|UniProtKB:P14646
|
source |
Swiss-Prot : SWS_FT_FI8
|
|
|
|