eF-site ID 1rdt-ABDE PDB Code 1rdt Chain A, B, D, E click to enlarge Title Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer Classification HORMONE/GROWTH FACTOR Compound Retinoic acid receptor RXR-alpha Source Homo sapiens (Human) (1RDT) Sequence A:  EDMPVERILEAELAVEPDPVTNICQAADKQLFTLVEWAKR IPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGIL LATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKT ELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCK HKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT PIDTFLMEMLE B:  HKILHRLLQ D:  AESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKS PFVIYDMNSLMEVAIRIFQGCQFRSVEAVQEITEYAKSIP GFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDL AIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLN HPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMS LHPLLQEIYKDLY E:  KQLSELL Description Functional site 1) chain A residue 268 type sequence I description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 2) chain A residue 271 type sequence A description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 3) chain A residue 272 type sequence A description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 4) chain A residue 275 type sequence Q description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 5) chain A residue 306 type sequence N description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 6) chain A residue 309 type sequence L description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 7) chain A residue 313 type sequence F description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 8) chain A residue 316 type sequence R description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 9) chain A residue 326 type sequence L description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 10) chain A residue 327 type sequence A description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 11) chain A residue 345 type sequence I description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 12) chain A residue 346 type sequence F description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 13) chain A residue 435 type sequence H description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 14) chain A residue 436 type sequence L description BINDING SITE FOR RESIDUE L79 A 463 source : AC1 15) chain D residue 282 type sequence F description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 16) chain D residue 284 type sequence G description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 17) chain D residue 285 type sequence C description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 18) chain D residue 286 type sequence Q description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 19) chain D residue 289 type sequence S description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 20) chain D residue 323 type sequence H description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 21) chain D residue 327 type sequence Y description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 22) chain D residue 330 type sequence L description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 23) chain D residue 341 type sequence I description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 24) chain D residue 348 type sequence M description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 25) chain D residue 363 type sequence F description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 26) chain D residue 449 type sequence H description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 27) chain D residue 465 type sequence L description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 28) chain D residue 469 type sequence L description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 29) chain D residue 473 type sequence Y description BINDING SITE FOR RESIDUE 570 D 478 source : AC2 30) chain D residue 323 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 449 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 473 type MOD_RES sequence Y description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 33) chain D residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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