eF-site ID 1ral-A PDB Code 1ral Chain A click to enlarge Title THREE-DIMENSIONAL STRUCTURE OF RAT LIVER 3ALPHA-HYDROXYSTEROID(SLASH)DIHYDRODIOL DEHYDROGENASE: A MEMBER OF THE ALDO-KETO REDUCTASE SUPERFAMILY Classification OXIDOREDUCTASE Compound 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE Source Rattus norvegicus (Rat) (DIDH_RAT) Sequence A:  MDSISLRVALNDGNFIPVLGFGTTVPEKVAKDEVIKATKI AIDNGFRHFDSAYLYEVEEEVGQAIRSKIEDGTVKREDIF YTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPM ALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLA KSIGVSNFNCRQLERILNKPGLKYKPVCNQVECHLYLNQS KMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPV LCAIAKKYKQTPALVALRYQLQRGVVPLIRSFNAKRIKEL TQVFEFQLASEDMKALDGLNRNFRYNNA Description Functional site 1) chain A residue 55 type ACT_SITE sequence Y description Proton donor source Swiss-Prot : SWS_FT_FI1 2) chain A residue 20 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9261071 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 50 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9261071 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 166 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9261071 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 190 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9261071 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 216 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9261071 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 270 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9261071 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 117 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI3 9) chain A residue 227 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI3 10) chain A residue 84 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 151-168 type prosite sequence MEKCKDAGLAKSIGVSNF description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MekckdaglAKSIGVSNF source prosite : PS00062 12) chain A residue 268-283 type prosite sequence LIRSFNAKRIKELTQV description ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. LIRSFNakRIkELtQV source prosite : PS00063 13) chain A residue 45-62 type prosite sequence GFRHFDSAYLYEVEEEVG description ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GFRHFDSAylyevEeeVG source prosite : PS00798 14) chain A residue 1 type MOD_RES sequence M description Blocked amino end (Met) source Swiss-Prot : SWS_FT_FI5

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