eF-site ID 1r6a-A
PDB Code 1r6a
Chain A

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Title Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Classification TRANSFERASE
Compound Genome polyprotein
Source Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2) (POLG_DEN2P)
Sequence A:  ETLGEKWKSRLNALGKSEFQIYKKSGIQEVDRTLAKEGIK
RGETDHHAVSRGSAKLRWFVERNLVTPEGKVVDLGCGRGG
WSYYCGGLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRL
QSGVDVFFIPPERCDTLLCDIGESSPNPTVEAGRTLRVLN
LVENWLSNNTQFCVKVLNPYMPSVIEKMEALQRKHGGALV
RNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMR
HKKATYEPDVDLGSGTRNIGIE
Description


Functional site

1) chain A
residue 109
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 901
source : AC1

2) chain A
residue 110
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 901
source : AC1

3) chain A
residue 111
type
sequence E
description BINDING SITE FOR RESIDUE SO4 A 901
source : AC1

4) chain A
residue 105
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC2

5) chain A
residue 110
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC2

6) chain A
residue 150
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC2

7) chain A
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC2

8) chain A
residue 160
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC2

9) chain A
residue 38
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 903
source : AC3

10) chain A
residue 56
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 903
source : AC3

11) chain A
residue 57
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 903
source : AC3

12) chain A
residue 84
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 903
source : AC3

13) chain A
residue 57
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 904
source : AC4

14) chain A
residue 61
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 904
source : AC4

15) chain A
residue 30
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC5

16) chain A
residue 57
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC5

17) chain A
residue 212
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC5

18) chain A
residue 105
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 906
source : AC6

19) chain A
residue 131
type
sequence D
description BINDING SITE FOR RESIDUE SO4 A 906
source : AC6

20) chain A
residue 156
type
sequence V
description BINDING SITE FOR RESIDUE SO4 A 906
source : AC6

21) chain A
residue 160
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 906
source : AC6

22) chain A
residue 163
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 906
source : AC6

23) chain A
residue 34
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC7

24) chain A
residue 52
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC7

25) chain A
residue 67
type
sequence E
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC7

26) chain A
residue 68
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC7

27) chain A
residue 246
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC7

28) chain A
residue 247
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC7

29) chain A
residue 56
type
sequence S
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

30) chain A
residue 58
type
sequence G
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

31) chain A
residue 81
type
sequence G
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

32) chain A
residue 82
type
sequence C
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

33) chain A
residue 83
type
sequence G
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

34) chain A
residue 86
type
sequence G
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

35) chain A
residue 87
type
sequence W
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

36) chain A
residue 104
type
sequence T
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

37) chain A
residue 105
type
sequence K
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

38) chain A
residue 130
type
sequence V
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

39) chain A
residue 131
type
sequence D
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

40) chain A
residue 132
type
sequence V
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

41) chain A
residue 133
type
sequence F
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

42) chain A
residue 146
type
sequence D
description BINDING SITE FOR RESIDUE SAH A 887
source : AC8

43) chain A
residue 14
type
sequence K
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

44) chain A
residue 17
type
sequence L
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

45) chain A
residue 18
type
sequence N
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

46) chain A
residue 20
type
sequence L
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

47) chain A
residue 22
type
sequence K
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

48) chain A
residue 25
type
sequence F
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

49) chain A
residue 29
type
sequence K
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

50) chain A
residue 150
type
sequence S
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

51) chain A
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

52) chain A
residue 152
type
sequence P
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

53) chain A
residue 214
type
sequence S
description BINDING SITE FOR RESIDUE RVP A 300
source : AC9

54) chain A
residue 56
type BINDING
sequence S
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

55) chain A
residue 86
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

56) chain A
residue 87
type BINDING
sequence W
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

57) chain A
residue 104
type BINDING
sequence T
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

58) chain A
residue 105
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

59) chain A
residue 131
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

60) chain A
residue 132
type BINDING
sequence V
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

61) chain A
residue 147
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

62) chain A
residue 219
type BINDING
sequence Y
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI2

63) chain A
residue 14
type SITE
sequence K
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI3

64) chain A
residue 18
type SITE
sequence N
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI3

65) chain A
residue 25
type SITE
sequence F
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI3

66) chain A
residue 29
type SITE
sequence K
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI3

67) chain A
residue 150
type SITE
sequence S
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI3

68) chain A
residue 212
type SITE
sequence R
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI3

69) chain A
residue 214
type SITE
sequence S
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI3

70) chain A
residue 17
type SITE
sequence L
description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI4

71) chain A
residue 20
type SITE
sequence L
description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI4

72) chain A
residue 61
type SITE
sequence K
description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI5

73) chain A
residue 181
type SITE
sequence K
description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI5

74) chain A
residue 217
type SITE
sequence E
description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI5

75) chain A
residue 61
type ACT_SITE
sequence K
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

76) chain A
residue 146
type ACT_SITE
sequence D
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

77) chain A
residue 181
type ACT_SITE
sequence K
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

78) chain A
residue 217
type ACT_SITE
sequence E
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

79) chain A
residue 146
type SITE
sequence D
description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI6

80) chain A
residue 56
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P03314
source Swiss-Prot : SWS_FT_FI7


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