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eF-site ID
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1r5w-ABCDEF |
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PDB Code
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1r5w |
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Chain
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A, B, C, D, E, F |
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click to enlarge
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Title
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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation |
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Classification
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SIGNALING PROTEIN |
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Compound
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H-2 class II histocompatibility antigen, E-K alpha chain |
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Source
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Mus musculus (Mouse) (1R5W) |
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Sequence
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A: |
EEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETI
WRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPD
ANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWL
RNGRPVTEGVSETVFLPRDDHLFRKFHYLTFLPSTDDFYD
CEVDHWGLEEPLRKHWEFEE
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| B: |
APWFLEYSKSECHFYNGTQRVRLLVRYFYNLEENLRFDSD
VGEFRAVTELGRPDAENWNSQPEFLEQKRAEVDTVCRHNY
EIFDNFLVPRRVEPTVTVYPTKTQPLEHHNLLVCSVSDFY
PGNIEVRWFRNGKEEKTGIVSTGLVRNGDWTFQTLVMLET
VPQSGEVYTCQVEHPSLTDPVTVEW
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| C: |
EEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETI
WRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPD
ANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWL
RNGRPVTEGVSETVFLPRDDHLFRKFHYLTFLPSTDDFYD
CEVDHWGLEEPLRKHWEFEE
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| D: |
APWFLEYSKSECHFYNGTQRVRLLVRYFYNLEENLRFDSD
VGEFRAVTELGRPDAENWNSQPEFLEQKRAEVDTVCRHNY
EIFDNFLVPRRVEPTVTVYPTKTQPLEHHNLLVCSVSDFY
PGNIEVRWFRNGKEEKTGIVSTGLVRNGDWTFQTLVMLET
VPQSGEVYTCQVEHPSLTDPVTVEW
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| E: |
ADLIAYFKAATKF
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| F: |
ADLIAYFKAATKF
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Description
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Functional site
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1)
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chain |
A |
| residue |
118 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
|
chain |
C |
| residue |
118 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
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chain |
A |
| residue |
161-167 |
| type |
prosite |
| sequence |
YDCEVDH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCEVDH
|
| source |
prosite : PS00290
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4)
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chain |
B |
| residue |
198-204 |
| type |
prosite |
| sequence |
YTCQVEH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCEVDH
|
| source |
prosite : PS00290
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