eF-site ID 1r55-A PDB Code 1r55 Chain A click to enlarge Title Crystal structure of the catalytic domain of human ADAM 33 Classification HYDROLASE Compound ADAM 33 Source Homo sapiens (Human) (AD33_HUMAN) Sequence A:  TRKYLELYIVADHTLFLTRHRNLQHTKQRLLEVANYVDQL LRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRR GLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGG VSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAE SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSN APS Description Functional site 1) chain A residue 342-351 type prosite sequence TMAHEIGHSL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMAHEIGHSL source prosite : PS00142 2) chain A residue 346 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 345 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14659745 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 349 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14659745 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 355 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14659745 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 231 type CARBOHYD sequence Q description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI3 7) chain A residue 276 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI3

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