eF-site ID 1r35-A PDB Code 1r35 Chain A click to enlarge Title MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER, TETRAHYDROBIOPTERIN AND 4R-FLUORO-N6-ETHANIMIDOYL-L-LYSINE Classification OXIDOREDUCTASE Compound Nitric oxide synthase, inducible Source Mus musculus (Mouse) (NOS2_MOUSE) Sequence A:  QYVRIKNWGSGEILHDTLHHKATSSCLGSIMNPKSLTRGP RDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAV TKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNL QVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQ RSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQL CIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEV TMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPF NGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASL WKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQN EYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFY YYQIEPWKTHIWQ Description Functional site 1) chain A residue 97 type sequence K description BINDING SITE FOR RESIDUE SO4 A 903 source : AC1 2) chain A residue 448 type sequence R description BINDING SITE FOR RESIDUE SO4 A 903 source : AC1 3) chain A residue 188 type sequence W description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 4) chain A residue 193 type sequence R description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 5) chain A residue 194 type sequence C description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 6) chain A residue 195 type sequence I description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 7) chain A residue 236 type sequence S description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 8) chain A residue 349 type sequence M description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 9) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 10) chain A residue 364 type sequence N description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 11) chain A residue 365 type sequence G description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 12) chain A residue 366 type sequence W description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 13) chain A residue 371 type sequence E description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 14) chain A residue 457 type sequence W description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 15) chain A residue 485 type sequence Y description BINDING SITE FOR RESIDUE HEM A 901 source : AC2 16) chain A residue 112 type sequence S description BINDING SITE FOR RESIDUE H4B A 902 source : AC3 17) chain A residue 114 type sequence M description BINDING SITE FOR RESIDUE H4B A 902 source : AC3 18) chain A residue 375 type sequence R description BINDING SITE FOR RESIDUE H4B A 902 source : AC3 19) chain A residue 455 type sequence W description BINDING SITE FOR RESIDUE H4B A 902 source : AC3 20) chain A residue 456 type sequence I description BINDING SITE FOR RESIDUE H4B A 902 source : AC3 21) chain A residue 457 type sequence W description BINDING SITE FOR RESIDUE H4B A 902 source : AC3 22) chain A residue 470 type sequence F description BINDING SITE FOR RESIDUE H4B A 902 source : AC3 23) chain A residue 257 type sequence Q description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 24) chain A residue 341 type sequence Y description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 25) chain A residue 344 type sequence P description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 26) chain A residue 346 type sequence V description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 27) chain A residue 366 type sequence W description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 28) chain A residue 367 type sequence Y description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 29) chain A residue 371 type sequence E description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 30) chain A residue 376 type sequence D description BINDING SITE FOR RESIDUE I58 A 800 source : AC4 31) chain A residue 257 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 32) chain A residue 366 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 367 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 371 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 193-200 type prosite sequence RCIGRIQW description NOS Nitric oxide synthase (NOS) signature. RCIGRIqW source prosite : PS60001 36) chain A residue 375 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI5 37) chain A residue 456 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N source Swiss-Prot : SWS_FT_FI6 38) chain A residue 457 type BINDING sequence W description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI7 39) chain A residue 470 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI8 40) chain A residue 485 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI9 41) chain A residue 112 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI2 42) chain A residue 109 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1N2N source Swiss-Prot : SWS_FT_FI1 43) chain A residue 194 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9334294, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOC, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1NOS, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:2NOS, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI3

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