eF-site ID 1r15-ABCDEFGH PDB Code 1r15 Chain A, B, C, D, E, F, G, H click to enlarge Title Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P Classification HYDROLASE Compound ADP-ribosyl cyclase Source Aplysia californica (California sea hare) (NADA_APLCA) Sequence A:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA B:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA C:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA D:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA E:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA F:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA G:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA H:  IVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKD FFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGV YDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGF NEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVD GSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGE KIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCS DNPNARECRLA Description (1)  ADP-ribosyl cyclase (E.C.3.2.2.5) Functional site 1) chain A residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA A 319 source : AC1 2) chain A residue 108 type sequence S description BINDING SITE FOR RESIDUE NCA A 319 source : AC1 3) chain A residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA A 319 source : AC1 4) chain B residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA B 329 source : AC2 5) chain B residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA B 329 source : AC2 6) chain C residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA C 339 source : AC3 7) chain C residue 107 type sequence N description BINDING SITE FOR RESIDUE NCA C 339 source : AC3 8) chain C residue 108 type sequence S description BINDING SITE FOR RESIDUE NCA C 339 source : AC3 9) chain C residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA C 339 source : AC3 10) chain D residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA D 349 source : AC4 11) chain D residue 107 type sequence N description BINDING SITE FOR RESIDUE NCA D 349 source : AC4 12) chain D residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA D 349 source : AC4 13) chain H residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA H 389 source : AC5 14) chain H residue 107 type sequence N description BINDING SITE FOR RESIDUE NCA H 389 source : AC5 15) chain H residue 108 type sequence S description BINDING SITE FOR RESIDUE NCA H 389 source : AC5 16) chain H residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA H 389 source : AC5 17) chain B residue 110 type sequence V description BINDING SITE FOR RESIDUE NCA B 429 source : AC6 18) chain B residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA B 429 source : AC6 19) chain B residue 136 type sequence R description BINDING SITE FOR RESIDUE NCA B 429 source : AC6 20) chain B residue 139 type sequence F description BINDING SITE FOR RESIDUE NCA B 429 source : AC6 21) chain B residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA B 429 source : AC6 22) chain D residue 110 type sequence V description BINDING SITE FOR RESIDUE NCA D 449 source : AC7 23) chain D residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA D 449 source : AC7 24) chain D residue 136 type sequence R description BINDING SITE FOR RESIDUE NCA D 449 source : AC7 25) chain D residue 139 type sequence F description BINDING SITE FOR RESIDUE NCA D 449 source : AC7 26) chain D residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA D 449 source : AC7 27) chain F residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA F 469 source : AC8 28) chain F residue 136 type sequence R description BINDING SITE FOR RESIDUE NCA F 469 source : AC8 29) chain F residue 139 type sequence F description BINDING SITE FOR RESIDUE NCA F 469 source : AC8 30) chain F residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA F 469 source : AC8 31) chain H residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA H 489 source : AC9 32) chain H residue 136 type sequence R description BINDING SITE FOR RESIDUE NCA H 489 source : AC9 33) chain H residue 139 type sequence F description BINDING SITE FOR RESIDUE NCA H 489 source : AC9 34) chain H residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA H 489 source : AC9 35) chain G residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA G 479 source : BC1 36) chain G residue 136 type sequence R description BINDING SITE FOR RESIDUE NCA G 479 source : BC1 37) chain G residue 139 type sequence F description BINDING SITE FOR RESIDUE NCA G 479 source : BC1 38) chain G residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA G 479 source : BC1 39) chain E residue 110 type sequence V description BINDING SITE FOR RESIDUE NCA E 459 source : BC2 40) chain E residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA E 459 source : BC2 41) chain E residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA E 459 source : BC2 42) chain C residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA C 439 source : BC3 43) chain C residue 136 type sequence R description BINDING SITE FOR RESIDUE NCA C 439 source : BC3 44) chain C residue 139 type sequence F description BINDING SITE FOR RESIDUE NCA C 439 source : BC3 45) chain C residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA C 439 source : BC3 46) chain A residue 110 type sequence V description BINDING SITE FOR RESIDUE NCA A 419 source : BC4 47) chain A residue 111 type sequence W description BINDING SITE FOR RESIDUE NCA A 419 source : BC4 48) chain A residue 139 type sequence F description BINDING SITE FOR RESIDUE NCA A 419 source : BC4 49) chain A residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA A 419 source : BC4 50) chain G residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA G 379 source : BC5 51) chain G residue 107 type sequence N description BINDING SITE FOR RESIDUE NCA G 379 source : BC5 52) chain G residue 108 type sequence S description BINDING SITE FOR RESIDUE NCA G 379 source : BC5 53) chain G residue 140 type sequence W description BINDING SITE FOR RESIDUE NCA G 379 source : BC5 54) chain F residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA F 369 source : BC6 55) chain F residue 107 type sequence N description BINDING SITE FOR RESIDUE NCA F 369 source : BC6 56) chain E residue 98 type sequence E description BINDING SITE FOR RESIDUE NCA E 359 source : BC7 57) chain E residue 107 type sequence N description BINDING SITE FOR RESIDUE NCA E 359 source : BC7 58) chain A residue 77 type sequence W description BINDING SITE FOR RESIDUE N A 1179 source : BC8 59) chain A residue 78 type sequence S description BINDING SITE FOR RESIDUE N A 1179 source : BC8 60) chain A residue 79 type sequence G description BINDING SITE FOR RESIDUE N A 1179 source : BC8 61) chain A residue 97 type sequence L description BINDING SITE FOR RESIDUE N A 1179 source : BC8 62) chain A residue 173 type sequence S description BINDING SITE FOR RESIDUE N A 1179 source : BC8 63) chain A residue 174 type sequence F description BINDING SITE FOR RESIDUE N A 1179 source : BC8 64) chain A residue 179 type sequence E description BINDING SITE FOR RESIDUE N A 1179 source : BC8 65) chain B residue 77 type sequence W description BINDING SITE FOR RESIDUE N B 1179 source : BC9 66) chain B residue 78 type sequence S description BINDING SITE FOR RESIDUE N B 1179 source : BC9 67) chain B residue 79 type sequence G description BINDING SITE FOR RESIDUE N B 1179 source : BC9 68) chain B residue 97 type sequence L description BINDING SITE FOR RESIDUE N B 1179 source : BC9 69) chain B residue 173 type sequence S description BINDING SITE FOR RESIDUE N B 1179 source : BC9 70) chain B residue 174 type sequence F description BINDING SITE FOR RESIDUE N B 1179 source : BC9 71) chain B residue 179 type sequence E description BINDING SITE FOR RESIDUE N B 1179 source : BC9 72) chain C residue 77 type sequence W description BINDING SITE FOR RESIDUE N C 1179 source : CC1 73) chain C residue 78 type sequence S description BINDING SITE FOR RESIDUE N C 1179 source : CC1 74) chain C residue 79 type sequence G description BINDING SITE FOR RESIDUE N C 1179 source : CC1 75) chain C residue 97 type sequence L description BINDING SITE FOR RESIDUE N C 1179 source : CC1 76) chain C residue 173 type sequence S description BINDING SITE FOR RESIDUE N C 1179 source : CC1 77) chain C residue 174 type sequence F description BINDING SITE FOR RESIDUE N C 1179 source : CC1 78) chain C residue 179 type sequence E description BINDING SITE FOR RESIDUE N C 1179 source : CC1 79) chain D residue 77 type sequence W description BINDING SITE FOR RESIDUE N D 1179 source : CC2 80) chain D residue 78 type sequence S description BINDING SITE FOR RESIDUE N D 1179 source : CC2 81) chain D residue 79 type sequence G description BINDING SITE FOR RESIDUE N D 1179 source : CC2 82) chain D residue 97 type sequence L description BINDING SITE FOR RESIDUE N D 1179 source : CC2 83) chain D residue 173 type sequence S description BINDING SITE FOR RESIDUE N D 1179 source : CC2 84) chain D residue 174 type sequence F description BINDING SITE FOR RESIDUE N D 1179 source : CC2 85) chain D residue 179 type sequence E description BINDING SITE FOR RESIDUE N D 1179 source : CC2 86) chain E residue 77 type sequence W description BINDING SITE FOR RESIDUE N E 1179 source : CC3 87) chain E residue 78 type sequence S description BINDING SITE FOR RESIDUE N E 1179 source : CC3 88) chain E residue 79 type sequence G description BINDING SITE FOR RESIDUE N E 1179 source : CC3 89) chain E residue 97 type sequence L description BINDING SITE FOR RESIDUE N E 1179 source : CC3 90) chain E residue 144 type sequence S description BINDING SITE FOR RESIDUE N E 1179 source : CC3 91) chain E residue 173 type sequence S description BINDING SITE FOR RESIDUE N E 1179 source : CC3 92) chain E residue 174 type sequence F description BINDING SITE FOR RESIDUE N E 1179 source : CC3 93) chain E residue 179 type sequence E description BINDING SITE FOR RESIDUE N E 1179 source : CC3 94) chain F residue 77 type sequence W description BINDING SITE FOR RESIDUE N F 1179 source : CC4 95) chain F residue 78 type sequence S description BINDING SITE FOR RESIDUE N F 1179 source : CC4 96) chain F residue 79 type sequence G description BINDING SITE FOR RESIDUE N F 1179 source : CC4 97) chain F residue 97 type sequence L description BINDING SITE FOR RESIDUE N F 1179 source : CC4 98) chain F residue 173 type sequence S description BINDING SITE FOR RESIDUE N F 1179 source : CC4 99) chain F residue 174 type sequence F description BINDING SITE FOR RESIDUE N F 1179 source : CC4 100) chain F residue 179 type sequence E description BINDING SITE FOR RESIDUE N F 1179 source : CC4 101) chain G residue 77 type sequence W description BINDING SITE FOR RESIDUE N G 1179 source : CC5 102) chain G residue 78 type sequence S description BINDING SITE FOR RESIDUE N G 1179 source : CC5 103) chain G residue 79 type sequence G description BINDING SITE FOR RESIDUE N G 1179 source : CC5 104) chain G residue 97 type sequence L description BINDING SITE FOR RESIDUE N G 1179 source : CC5 105) chain G residue 173 type sequence S description BINDING SITE FOR RESIDUE N G 1179 source : CC5 106) chain G residue 174 type sequence F description BINDING SITE FOR RESIDUE N G 1179 source : CC5 107) chain G residue 179 type sequence E description BINDING SITE FOR RESIDUE N G 1179 source : CC5 108) chain H residue 77 type sequence W description BINDING SITE FOR RESIDUE N H 1179 source : CC6 109) chain H residue 78 type sequence S description BINDING SITE FOR RESIDUE N H 1179 source : CC6 110) chain H residue 79 type sequence G description BINDING SITE FOR RESIDUE N H 1179 source : CC6 111) chain H residue 97 type sequence L description BINDING SITE FOR RESIDUE N H 1179 source : CC6 112) chain H residue 144 type sequence S description BINDING SITE FOR RESIDUE N H 1179 source : CC6 113) chain H residue 173 type sequence S description BINDING SITE FOR RESIDUE N H 1179 source : CC6 114) chain H residue 174 type sequence F description BINDING SITE FOR RESIDUE N H 1179 source : CC6 115) chain H residue 179 type sequence E description BINDING SITE FOR RESIDUE N H 1179 source : CC6 116) chain A residue 98 type catalytic sequence E description 607 source MCSA : MCSA1 117) chain A residue 174 type catalytic sequence F description 607 source MCSA : MCSA1 118) chain A residue 179 type catalytic sequence E description 607 source MCSA : MCSA1 119) chain B residue 98 type catalytic sequence E description 607 source MCSA : MCSA2 120) chain B residue 174 type catalytic sequence F description 607 source MCSA : MCSA2 121) chain B residue 179 type catalytic sequence E description 607 source MCSA : MCSA2 122) chain C residue 98 type catalytic sequence E description 607 source MCSA : MCSA3 123) chain C residue 174 type catalytic sequence F description 607 source MCSA : MCSA3 124) chain C residue 179 type catalytic sequence E description 607 source MCSA : MCSA3 125) chain D residue 98 type catalytic sequence E description 607 source MCSA : MCSA4 126) chain D residue 174 type catalytic sequence F description 607 source MCSA : MCSA4 127) chain D residue 179 type catalytic sequence E description 607 source MCSA : MCSA4 128) chain E residue 98 type catalytic sequence E description 607 source MCSA : MCSA5 129) chain E residue 174 type catalytic sequence F description 607 source MCSA : MCSA5 130) chain E residue 179 type catalytic sequence E description 607 source MCSA : MCSA5 131) chain F residue 98 type catalytic sequence E description 607 source MCSA : MCSA6 132) chain F residue 174 type catalytic sequence F description 607 source MCSA : MCSA6 133) chain F residue 179 type catalytic sequence E description 607 source MCSA : MCSA6 134) chain G residue 98 type catalytic sequence E description 607 source MCSA : MCSA7 135) chain G residue 174 type catalytic sequence F description 607 source MCSA : MCSA7 136) chain G residue 179 type catalytic sequence E description 607 source MCSA : MCSA7 137) chain H residue 98 type catalytic sequence E description 607 source MCSA : MCSA8 138) chain H residue 174 type catalytic sequence F description 607 source MCSA : MCSA8 139) chain H residue 179 type catalytic sequence E description 607 source MCSA : MCSA8

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