eF-site ID 1r0x-A
PDB Code 1r0x
Chain A

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Title Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP
Classification TRANSPORT PROTEIN
Compound Cystic fibrosis transmembrane conductance regulator
Source (CFTR_MOUSE)
Sequence A:  TGIIMENVTAFWEEGFGELLEKSFSHLCLVGNPVLKNINL
NIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSG
RVSFCSQFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQL
QQDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDA
DLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSK
MEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMG
YDTFDQFTEERRSSILTETLRRFS
Description


Functional site

1) chain A
residue 465
type
sequence T
description BINDING SITE FOR RESIDUE MG A 13
source : AC3

2) chain A
residue 493
type
sequence Q
description BINDING SITE FOR RESIDUE MG A 13
source : AC3

3) chain A
residue 401
type
sequence W
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

4) chain A
residue 409
type
sequence L
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

5) chain A
residue 430
type
sequence F
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

6) chain A
residue 460
type
sequence T
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

7) chain A
residue 461
type
sequence G
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

8) chain A
residue 462
type
sequence S
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

9) chain A
residue 463
type
sequence G
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

10) chain A
residue 464
type
sequence K
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

11) chain A
residue 465
type
sequence T
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

12) chain A
residue 466
type
sequence S
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

13) chain A
residue 493
type
sequence Q
description BINDING SITE FOR RESIDUE ATP A 1
source : AC5

14) chain A
residue 541
type
sequence L
description BINDING SITE FOR RESIDUE ACY A 5
source : AC9

15) chain A
residue 542
type
sequence G
description BINDING SITE FOR RESIDUE ACY A 5
source : AC9

16) chain A
residue 545
type
sequence G
description BINDING SITE FOR RESIDUE ACY A 5
source : AC9

17) chain A
residue 546
type
sequence V
description BINDING SITE FOR RESIDUE ACY A 5
source : AC9

18) chain A
residue 547
type
sequence T
description BINDING SITE FOR RESIDUE ACY A 5
source : AC9

19) chain A
residue 532
type
sequence K
description BINDING SITE FOR RESIDUE ACY A 10
source : BC5

20) chain A
residue 549
type
sequence S
description BINDING SITE FOR RESIDUE ACY A 10
source : BC5

21) chain A
residue 552
type
sequence Q
description BINDING SITE FOR RESIDUE ACY A 10
source : BC5

22) chain A
residue 548-562
type prosite
sequence LSGGQRARISLARAV
description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV
source prosite : PS00211

23) chain A
residue 401
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P13569
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 458
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0007744|PDB:1Q3H, ECO:0007744|PDB:1R0X, ECO:0007744|PDB:1R0Z, ECO:0007744|PDB:1R10, ECO:0007744|PDB:1XF9, ECO:0007744|PDB:1XFA, ECO:0007744|PDB:3SI7
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 493
type BINDING
sequence Q
description BINDING => ECO:0007744|PDB:1Q3H, ECO:0007744|PDB:1R0X, ECO:0007744|PDB:1R0Z, ECO:0007744|PDB:1XFA
source Swiss-Prot : SWS_FT_FI3

26) chain A
residue 549
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P13569
source Swiss-Prot : SWS_FT_FI4

27) chain A
residue 660
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P13569
source Swiss-Prot : SWS_FT_FI4

28) chain A
residue 670
type MOD_RES
sequence S
description Phosphoserine; by PKA => ECO:0000250|UniProtKB:P13569
source Swiss-Prot : SWS_FT_FI5

29) chain A
residue 524
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000250|UniProtKB:P13569
source Swiss-Prot : SWS_FT_FI6


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