eF-site ID 1qxs-C PDB Code 1qxs Chain C click to enlarge Title CRYSTAL STRUCTURE OF Trypanosoma cruzi GLYCERALDEHYDE-3- PHOSPHATE DEHYDROGENASE COMPLEXED WITH AN ANALOGUE OF 1,3- BisPHOSPHO-D-GLYCERIC ACID Classification OXIDOREDUCTASE Compound Glyceraldehyde 3-phosphate dehydrogenase, glycosomal Source null (G3PG_TRYCR) Sequence C:  MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMN TDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVV NGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAA EGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHV VSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQ KTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQ GKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRA SKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNL PKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL Description Functional site 1) chain C residue 8 type sequence N description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 2) chain C residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 3) chain C residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 4) chain C residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 5) chain C residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 6) chain C residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 7) chain C residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 8) chain C residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 9) chain C residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 10) chain C residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 11) chain C residue 112 type sequence G description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 12) chain C residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 13) chain C residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 14) chain C residue 135 type sequence A description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 15) chain C residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 16) chain C residue 198 type sequence A description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 17) chain C residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 18) chain C residue 339 type sequence Y description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 19) chain C residue 206 type sequence V description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 20) chain C residue 166 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 21) chain C residue 249 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 22) chain C residue 165 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI3 23) chain C residue 197 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 24) chain C residue 226 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 25) chain C residue 194 type SITE sequence H description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 26) chain C residue 164-171 type prosite sequence ASCTTNCL description GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL source prosite : PS00071 27) chain C residue 38 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 28) chain C residue 335 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 29) chain C residue 91 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 30) chain C residue 134 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 31) chain C residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2

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