eF-site ID 1qxs-ABCD PDB Code 1qxs Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF Trypanosoma cruzi GLYCERALDEHYDE-3- PHOSPHATE DEHYDROGENASE COMPLEXED WITH AN ANALOGUE OF 1,3- BisPHOSPHO-D-GLYCERIC ACID Classification OXIDOREDUCTASE Compound Glyceraldehyde 3-phosphate dehydrogenase, glycosomal Source Trypanosoma cruzi (G3PG_TRYCR) Sequence A:  MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMN TDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVV NGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAA EGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHV VSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQ KTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQ GKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRA SKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNL PKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL B:  MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMN TDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVV NGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAA EGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHV VSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQ KTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQ GKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRA SKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNL PKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL C:  MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMN TDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVV NGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAA EGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHV VSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQ KTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQ GKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRA SKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNL PKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL D:  MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMN TDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVV NGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAA EGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHV VSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQ KTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQ GKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRA SKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNL PKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL Description Functional site 1) chain C residue 8 type sequence N description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 2) chain C residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 3) chain C residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 4) chain C residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 5) chain C residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 6) chain C residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 7) chain C residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 8) chain C residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 9) chain C residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 10) chain C residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 11) chain C residue 112 type sequence G description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 12) chain C residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 13) chain C residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 14) chain C residue 135 type sequence A description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 15) chain C residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 16) chain C residue 198 type sequence A description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 17) chain C residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 18) chain C residue 339 type sequence Y description BINDING SITE FOR RESIDUE NAD C 860 source : AC1 19) chain D residue 8 type sequence N description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 20) chain D residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 21) chain D residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 22) chain D residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 23) chain D residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 24) chain D residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 25) chain D residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 26) chain D residue 90 type sequence A description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 27) chain D residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 28) chain D residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 29) chain D residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 30) chain D residue 112 type sequence G description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 31) chain D residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 32) chain D residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 33) chain D residue 135 type sequence A description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 34) chain D residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 35) chain D residue 198 type sequence A description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 36) chain D residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 37) chain D residue 339 type sequence Y description BINDING SITE FOR RESIDUE NAD D 861 source : AC2 38) chain A residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 39) chain A residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 40) chain A residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 41) chain A residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 42) chain A residue 37 type sequence V description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 43) chain A residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 44) chain A residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 45) chain A residue 90 type sequence A description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 46) chain A residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 47) chain A residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 48) chain A residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 49) chain A residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 50) chain A residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 51) chain A residue 135 type sequence A description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 52) chain A residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 53) chain A residue 198 type sequence A description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 54) chain A residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 55) chain A residue 339 type sequence Y description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 56) chain D residue 206 type sequence V description BINDING SITE FOR RESIDUE NAD A 862 source : AC3 57) chain B residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 58) chain B residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 59) chain B residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 60) chain B residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 61) chain B residue 37 type sequence V description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 62) chain B residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 63) chain B residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 64) chain B residue 90 type sequence A description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 65) chain B residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 66) chain B residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 67) chain B residue 112 type sequence G description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 68) chain B residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 69) chain B residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 70) chain B residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 71) chain B residue 198 type sequence A description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 72) chain B residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 73) chain B residue 336 type sequence E description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 74) chain C residue 206 type sequence V description BINDING SITE FOR RESIDUE NAD B 863 source : AC4 75) chain A residue 166 type sequence C description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 76) chain A residue 167 type sequence T description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 77) chain A residue 192 type sequence T description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 78) chain A residue 194 type sequence H description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 79) chain A residue 197 type sequence T description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 80) chain A residue 199 type sequence T description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 81) chain A residue 226 type sequence T description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 82) chain A residue 247 type sequence S description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 83) chain A residue 249 type sequence R description BINDING SITE FOR RESIDUE S70 A 804 source : AC5 84) chain C residue 164-171 type prosite sequence ASCTTNCL description GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL source prosite : PS00071 85) chain C residue 166 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 86) chain D residue 166 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 87) chain A residue 166 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 88) chain B residue 166 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 89) chain C residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 90) chain D residue 335 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 91) chain A residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 92) chain A residue 38 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 93) chain A residue 91 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 94) chain A residue 134 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 95) chain A residue 335 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 38 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 91 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 134 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 100) chain C residue 38 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 101) chain B residue 335 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 102) chain C residue 91 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 103) chain C residue 134 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 104) chain C residue 335 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 105) chain D residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 106) chain D residue 38 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 107) chain D residue 91 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 108) chain D residue 134 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12795610, ECO:0000269|PubMed:14622286 source Swiss-Prot : SWS_FT_FI2 109) chain C residue 165 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI3 110) chain A residue 197 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 111) chain A residue 226 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 112) chain A residue 249 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 113) chain B residue 165 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI3 114) chain B residue 197 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 115) chain B residue 226 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 116) chain B residue 249 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 117) chain C residue 197 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 118) chain C residue 226 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 119) chain C residue 249 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 120) chain D residue 165 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI3 121) chain D residue 197 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 122) chain D residue 226 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 123) chain D residue 249 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 124) chain A residue 165 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI3 125) chain C residue 194 type SITE sequence H description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 126) chain D residue 194 type SITE sequence H description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 127) chain A residue 194 type SITE sequence H description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 128) chain B residue 194 type SITE sequence H description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4

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