eF-site ID 1qu6_3-A PDB Code 1qu6 Model 3 Chain A click to enlarge Title STRUCTURE OF THE DOUBLE-STRANDED RNA-BINDING DOMAIN OF THE PROTEIN KINASE PKR REVEALS THE MOLECULAR BASIS OF ITS DSRNA-MEDIATED ACTIVATION Classification TRANSFERASE Compound PROTEIN KINASE PKR Source Homo sapiens (Human) (E2AK2_HUMAN) Sequence A:  GSHMEMAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGP PHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEIL NKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLT VNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQ LAAKLAYLQILSEETGSGC Description Functional site 1) chain A residue 7 type MOD_RES sequence A description N-acetylalanine => ECO:0000269|Ref.13, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 88 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:11152499, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 93 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:11152499 source Swiss-Prot : SWS_FT_FI3 4) chain A residue 94 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:11152499 source Swiss-Prot : SWS_FT_FI3 5) chain A residue 95 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:11152499 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 74 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:23229543 source Swiss-Prot : SWS_FT_FI5 7) chain A residue 164 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:23229543 source Swiss-Prot : SWS_FT_FI5 8) chain A residue 106 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16373505 source Swiss-Prot : SWS_FT_FI4 9) chain A residue 167 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16373505 source Swiss-Prot : SWS_FT_FI4

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