eF-site/Summary 1qjb-B

eF-site ID	1qjb-B
PDB Code	1qjb
Chain	B

click to enlarge

Title	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
Classification	KINASE INHIBITOR/PEPTIDE
Compound	14-3-3 PROTEIN ZETA/DELTA
Source	(1QJB)

Sequence	B:	MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEE RNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAR EYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLK MKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEM QPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAI AELDTLSEESYKDSTLIMQLLRDNLTLWTSDT

Description	(1)	14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE

Functional site


1)	chain	B
	residue	210
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000250\|UniProtKB:P63102
	source	Swiss-Prot : SWS_FT_FI7

2)	chain	B
	residue	232
	type	MOD_RES
	sequence	T
	description	Phosphothreonine; by CK1 => ECO:0000269\|PubMed:31024343, ECO:0000269\|PubMed:9360956, ECO:0007744\|PubMed:20068231
	source	Swiss-Prot : SWS_FT_FI8

3)	chain	B
	residue	56
	type	SITE
	sequence	R
	description	Interaction with phosphoserine on interacting protein => ECO:0000250\|UniProtKB:P63103
	source	Swiss-Prot : SWS_FT_FI1

4)	chain	B
	residue	127
	type	SITE
	sequence	R
	description	Interaction with phosphoserine on interacting protein => ECO:0000250\|UniProtKB:P63103
	source	Swiss-Prot : SWS_FT_FI1

5)	chain	B
	residue	1
	type	MOD_RES
	sequence	M
	description	N-acetylmethionine => ECO:0000269\|Ref.8, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712
	source	Swiss-Prot : SWS_FT_FI2

6)	chain	B
	residue	3
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI3

7)	chain	B
	residue	68
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI3

8)	chain	B
	residue	58
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269\|PubMed:11956222, ECO:0000269\|PubMed:12865427, ECO:0000269\|PubMed:15883165, ECO:0000269\|PubMed:16376338
	source	Swiss-Prot : SWS_FT_FI4

9)	chain	B
	residue	184
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by MAPK8 => ECO:0000269\|PubMed:15071501, ECO:0000269\|PubMed:15696159
	source	Swiss-Prot : SWS_FT_FI5

10)	chain	B
	residue	207
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231
	source	Swiss-Prot : SWS_FT_FI6