eF-site ID 1qhi-A PDB Code 1qhi Chain A click to enlarge Title HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE Classification TRANSFERASE Compound PROTEIN (THYMIDINE KINASE) Source Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) (KITH_HSV11) Sequence A:  MPTLLRVYIDGPHGMGKTTTTQLLVDIVYVPEPMTYWRVL GASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMP YAVTDAVLAPHIGGEAGPPALTLIFDRHPIAALLCYPAAR YLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDR LAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWR EDWGQLSGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWA LDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTH VTTPGSIPTICDLARTFAREMGEA Description Functional site 1) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE SO4 A 3 source : AC1 2) chain A residue 59 type sequence G description BINDING SITE FOR RESIDUE SO4 A 3 source : AC1 3) chain A residue 60 type sequence M description BINDING SITE FOR RESIDUE SO4 A 3 source : AC1 4) chain A residue 61 type sequence G description BINDING SITE FOR RESIDUE SO4 A 3 source : AC1 5) chain A residue 62 type sequence K description BINDING SITE FOR RESIDUE SO4 A 3 source : AC1 6) chain A residue 63 type sequence T description BINDING SITE FOR RESIDUE SO4 A 3 source : AC1 7) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3 source : AC1 8) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 9) chain A residue 83 type sequence E description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 10) chain A residue 100 type sequence I description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 11) chain A residue 101 type sequence Y description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 12) chain A residue 125 type sequence Q description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 13) chain A residue 128 type sequence M description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 14) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 15) chain A residue 163 type sequence R description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 16) chain A residue 168 type sequence A description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 17) chain A residue 172 type sequence Y description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 18) chain A residue 176 type sequence R description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 19) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE BPG A 1 source : AC3 20) chain A residue 62 type catalytic sequence K description 588 source MCSA : MCSA1 21) chain A residue 83 type catalytic sequence E description 588 source MCSA : MCSA1 22) chain A residue 162 type catalytic sequence D description 588 source MCSA : MCSA1 23) chain A residue 163 type catalytic sequence R description 588 source MCSA : MCSA1 24) chain A residue 220 type catalytic sequence R description 588 source MCSA : MCSA1 25) chain A residue 222 type catalytic sequence R description 588 source MCSA : MCSA1 26) chain A residue 225 type catalytic sequence E description 588 source MCSA : MCSA1 27) chain A residue 83 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_04029 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 56 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_04029 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 101 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_04029 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 125 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_04029 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 216 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04029 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 222 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04029 source Swiss-Prot : SWS_FT_FI2

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