eF-site ID 1qh3-AB PDB Code 1qh3 Chain A, B click to enlarge Title HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE Classification HYDROLASE Compound PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE) Source Homo sapiens (Human) (GLO2_HUMAN) Sequence A:  MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAA RKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDD RIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVL GRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWA KEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD PVTTMRAVRREKDQFKMPRD B:  MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAA RKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDD RIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVL GRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWA KEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD PVTTMRAVRREKDQFKMPRD Description Functional site 1) chain A residue 54 type sequence H description BINUCLEAR ZINC BINDING SITE IN A MOLECULE source : ZNA 2) chain A residue 56 type sequence H description BINUCLEAR ZINC BINDING SITE IN A MOLECULE source : ZNA 3) chain A residue 110 type sequence H description BINUCLEAR ZINC BINDING SITE IN A MOLECULE source : ZNA 4) chain A residue 134 type sequence D description BINUCLEAR ZINC BINDING SITE IN A MOLECULE source : ZNA 5) chain A residue 58 type sequence D description BINUCLEAR ZINC BINDING SITE IN A MOLECULE source : ZNA 6) chain A residue 59 type sequence H description BINUCLEAR ZINC BINDING SITE IN A MOLECULE source : ZNA 7) chain A residue 173 type sequence H description BINUCLEAR ZINC BINDING SITE IN A MOLECULE source : ZNA 8) chain B residue 54 type sequence H description BINUCLEAR ZINC BINDING SITE IN B MOLECULE source : ZNB 9) chain B residue 56 type sequence H description BINUCLEAR ZINC BINDING SITE IN B MOLECULE source : ZNB 10) chain B residue 110 type sequence H description BINUCLEAR ZINC BINDING SITE IN B MOLECULE source : ZNB 11) chain B residue 134 type sequence D description BINUCLEAR ZINC BINDING SITE IN B MOLECULE source : ZNB 12) chain B residue 58 type sequence D description BINUCLEAR ZINC BINDING SITE IN B MOLECULE source : ZNB 13) chain B residue 59 type sequence H description BINUCLEAR ZINC BINDING SITE IN B MOLECULE source : ZNB 14) chain B residue 173 type sequence H description BINUCLEAR ZINC BINDING SITE IN B MOLECULE source : ZNB 15) chain A residue 54 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC1 16) chain A residue 56 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC1 17) chain A residue 110 type sequence H description BINDING SITE FOR RESIDUE ZN A 261 source : AC1 18) chain A residue 134 type sequence D description BINDING SITE FOR RESIDUE ZN A 261 source : AC1 19) chain A residue 58 type sequence D description BINDING SITE FOR RESIDUE ZN A 262 source : AC2 20) chain A residue 59 type sequence H description BINDING SITE FOR RESIDUE ZN A 262 source : AC2 21) chain A residue 134 type sequence D description BINDING SITE FOR RESIDUE ZN A 262 source : AC2 22) chain A residue 173 type sequence H description BINDING SITE FOR RESIDUE ZN A 262 source : AC2 23) chain A residue 56 type sequence H description BINDING SITE FOR RESIDUE CAC A 463 source : AC3 24) chain A residue 58 type sequence D description BINDING SITE FOR RESIDUE CAC A 463 source : AC3 25) chain A residue 110 type sequence H description BINDING SITE FOR RESIDUE CAC A 463 source : AC3 26) chain A residue 134 type sequence D description BINDING SITE FOR RESIDUE CAC A 463 source : AC3 27) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE CAC A 463 source : AC3 28) chain A residue 173 type sequence H description BINDING SITE FOR RESIDUE CAC A 463 source : AC3 29) chain A residue 137 type sequence F description BINDING SITE FOR RESIDUE ACT A 464 source : AC4 30) chain A residue 141 type sequence C description BINDING SITE FOR RESIDUE ACT A 464 source : AC4 31) chain A residue 143 type sequence K description BINDING SITE FOR RESIDUE ACT A 464 source : AC4 32) chain A residue 175 type sequence Y description BINDING SITE FOR RESIDUE ACT A 464 source : AC4 33) chain A residue 249 type sequence R description BINDING SITE FOR RESIDUE ACT A 464 source : AC4 34) chain A residue 252 type sequence K description BINDING SITE FOR RESIDUE ACT A 464 source : AC4 35) chain A residue 153 type sequence C description BINDING SITE FOR RESIDUE CAC A 265 source : AC5 36) chain A residue 158 type sequence E description BINDING SITE FOR RESIDUE CAC A 265 source : AC5 37) chain A residue 185 type sequence H description BINDING SITE FOR RESIDUE MN A 266 source : AC6 38) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE MN A 266 source : AC6 39) chain A residue 251 type sequence E description BINDING SITE FOR RESIDUE MN A 266 source : AC6 40) chain B residue 54 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC8 41) chain B residue 56 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC8 42) chain B residue 110 type sequence H description BINDING SITE FOR RESIDUE ZN B 261 source : AC8 43) chain B residue 134 type sequence D description BINDING SITE FOR RESIDUE ZN B 261 source : AC8 44) chain B residue 58 type sequence D description BINDING SITE FOR RESIDUE ZN B 262 source : AC9 45) chain B residue 59 type sequence H description BINDING SITE FOR RESIDUE ZN B 262 source : AC9 46) chain B residue 134 type sequence D description BINDING SITE FOR RESIDUE ZN B 262 source : AC9 47) chain B residue 173 type sequence H description BINDING SITE FOR RESIDUE ZN B 262 source : AC9 48) chain B residue 56 type sequence H description BINDING SITE FOR RESIDUE CAC B 469 source : BC1 49) chain B residue 58 type sequence D description BINDING SITE FOR RESIDUE CAC B 469 source : BC1 50) chain B residue 110 type sequence H description BINDING SITE FOR RESIDUE CAC B 469 source : BC1 51) chain B residue 134 type sequence D description BINDING SITE FOR RESIDUE CAC B 469 source : BC1 52) chain B residue 173 type sequence H description BINDING SITE FOR RESIDUE CAC B 469 source : BC1 53) chain B residue 175 type sequence Y description BINDING SITE FOR RESIDUE CAC B 469 source : BC1 54) chain B residue 137 type sequence F description BINDING SITE FOR RESIDUE ACT B 468 source : BC2 55) chain B residue 141 type sequence C description BINDING SITE FOR RESIDUE ACT B 468 source : BC2 56) chain B residue 175 type sequence Y description BINDING SITE FOR RESIDUE ACT B 468 source : BC2 57) chain B residue 249 type sequence R description BINDING SITE FOR RESIDUE ACT B 468 source : BC2 58) chain B residue 252 type sequence K description BINDING SITE FOR RESIDUE ACT B 468 source : BC2 59) chain B residue 153 type sequence C description BINDING SITE FOR RESIDUE CAC B 265 source : BC3 60) chain B residue 154 type sequence K description BINDING SITE FOR RESIDUE CAC B 265 source : BC3 61) chain B residue 158 type sequence E description BINDING SITE FOR RESIDUE CAC B 265 source : BC3 62) chain B residue 185 type sequence H description BINDING SITE FOR RESIDUE MN B 266 source : BC4 63) chain B residue 251 type sequence E description BINDING SITE FOR RESIDUE MN B 266 source : BC4 64) chain A residue 102 type catalytic sequence V description 157 source MCSA : MCSA1 65) chain A residue 104 type catalytic sequence C description 157 source MCSA : MCSA1 66) chain A residue 106 type catalytic sequence A description 157 source MCSA : MCSA1 67) chain A residue 107 type catalytic sequence T description 157 source MCSA : MCSA1 68) chain A residue 158 type catalytic sequence E description 157 source MCSA : MCSA1 69) chain A residue 182 type catalytic sequence F description 157 source MCSA : MCSA1 70) chain A residue 221 type catalytic sequence Y description 157 source MCSA : MCSA1 71) chain B residue 102 type catalytic sequence V description 157 source MCSA : MCSA2 72) chain B residue 104 type catalytic sequence C description 157 source MCSA : MCSA2 73) chain B residue 106 type catalytic sequence A description 157 source MCSA : MCSA2 74) chain B residue 107 type catalytic sequence T description 157 source MCSA : MCSA2 75) chain B residue 158 type catalytic sequence E description 157 source MCSA : MCSA2 76) chain B residue 182 type catalytic sequence F description 157 source MCSA : MCSA2 77) chain B residue 221 type catalytic sequence Y description 157 source MCSA : MCSA2 78) chain A residue 229 type MOD_RES sequence E description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99KB8 source Swiss-Prot : SWS_FT_FI3 79) chain B residue 229 type MOD_RES sequence E description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99KB8 source Swiss-Prot : SWS_FT_FI3 80) chain A residue 102 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 104 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 82) chain B residue 106 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 83) chain B residue 107 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 158 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 182 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 191 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 221 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 88) chain A residue 104 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 89) chain A residue 106 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 90) chain A residue 107 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 91) chain A residue 158 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 92) chain A residue 182 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 191 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 94) chain A residue 221 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 95) chain B residue 102 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10508780 source Swiss-Prot : SWS_FT_FI1 96) chain A residue 116 type MOD_RES sequence C description N6-acetyllysine => ECO:0000250|UniProtKB:Q99KB8 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 116 type MOD_RES sequence C description N6-acetyllysine => ECO:0000250|UniProtKB:Q99KB8 source Swiss-Prot : SWS_FT_FI2

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