eF-site ID 1qfe-A PDB Code 1qfe Chain A click to enlarge Title THE STRUCTURE OF TYPE I 3-DEHYDROQUINATE DEHYDRATASE FROM SALMONELLA TYPHI Classification LYASE Compound PROTEIN (3-DEHYDROQUINATE DEHYDRATASE) Source ORGANISM_SCIENTIFIC: Salmonella typhi; Sequence A:  MKTVTVKNLIIGEGMPKIIVSLMGRDINSVKAEALAYREA TFDILEWRVDHFMDIASTQSVLTAARVIRDAMPDIPLLFT FRSAKEGGEQTITTQHYLTLNRAAIDSGLVDMIDLELFTG DADVKATVDYAHAHNVYVVMSNHDFHQTPSAEEMVSRLRK MQALGADIPKIAVMPQSKHDVLTLLTATLEMQQHYADRPV ITMSMAKEGVISRLAGEVFGSAATFGAVKQASAPGQIAVN DLRSVLMILHNA Description Functional site 1) chain A residue 170 type sequence K description LYS 170 FORMS THE IMINE INTERMEDIATE WITH THE AID OF HIS 143 ARG 213 INTERACTS WITH THE CARBOXYL GROUP OF THE 3-DEHYDROQUINATE SUBSTRATE. source : ASR 2) chain A residue 143 type sequence H description LYS 170 FORMS THE IMINE INTERMEDIATE WITH THE AID OF HIS 143 ARG 213 INTERACTS WITH THE CARBOXYL GROUP OF THE 3-DEHYDROQUINATE SUBSTRATE. source : ASR 3) chain A residue 213 type sequence R description LYS 170 FORMS THE IMINE INTERMEDIATE WITH THE AID OF HIS 143 ARG 213 INTERACTS WITH THE CARBOXYL GROUP OF THE 3-DEHYDROQUINATE SUBSTRATE. source : ASR 4) chain A residue 21 type sequence S description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 5) chain A residue 46 type sequence E description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 6) chain A residue 48 type sequence R description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 7) chain A residue 82 type sequence R description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 8) chain A residue 143 type sequence H description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 9) chain A residue 170 type sequence K description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 10) chain A residue 203 type sequence M description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 11) chain A residue 213 type sequence R description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 12) chain A residue 225 type sequence F description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 13) chain A residue 232 type sequence S description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 14) chain A residue 233 type sequence A description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 15) chain A residue 236 type sequence Q description BINDING SITE FOR RESIDUE DHS A 301 source : AC1 16) chain A residue 86 type catalytic sequence E description 54 source MCSA : MCSA1 17) chain A residue 143 type catalytic sequence H description 54 source MCSA : MCSA1 18) chain A residue 170 type catalytic sequence K description 54 source MCSA : MCSA1 19) chain A residue 114-144 type prosite sequence DLELFTGDADVKATVDYAHAHNVYVVMSNHD description DEHYDROQUINASE_I Dehydroquinase class I active site. DLELftgdadvkatvdyahahnvyVVmSNHD source prosite : PS01028 20) chain A residue 143 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000305|PubMed:24957267 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 170 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:10360352, ECO:0000269|PubMed:11976491 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 21 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:10360352, ECO:0000269|PubMed:11976491 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 232 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:10360352, ECO:0000269|PubMed:11976491 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 46 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:10360352, ECO:0000269|PubMed:11976491, ECO:0000269|PubMed:24957267 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 213 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:10360352, ECO:0000269|PubMed:11976491, ECO:0000269|PubMed:24957267 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 236 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:10360352, ECO:0000269|PubMed:11976491, ECO:0000269|PubMed:24957267 source Swiss-Prot : SWS_FT_FI4 27) chain A residue 82 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:10360352 source Swiss-Prot : SWS_FT_FI5

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