eF-site ID 1qf2-A PDB Code 1qf2 Chain A click to enlarge Title THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-GLY-(5-PHENYLPROLINE). PARAMETERS FOR ZN-MONODENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE Classification HYDROLASE Compound PROTEIN (THERMOLYSIN) Source ORGANISM_SCIENTIFIC: Bacillus thermoproteolyticus; Sequence A:  ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGDGIF TYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVT YDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSEM VYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNE SGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGD SLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKA AYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSN FSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK Description Functional site 1) chain A residue 146 type sequence H description ZN BINDING SITE source : ZN 2) chain A residue 142 type sequence H description ZN BINDING SITE source : ZN 3) chain A residue 166 type sequence E description ZN BINDING SITE source : ZN 4) chain A residue 142 type sequence H description BINDING SITE FOR RESIDUE ZN A 320 source : AC1 5) chain A residue 146 type sequence H description BINDING SITE FOR RESIDUE ZN A 320 source : AC1 6) chain A residue 166 type sequence E description BINDING SITE FOR RESIDUE ZN A 320 source : AC1 7) chain A residue 138 type sequence D description BINDING SITE FOR RESIDUE CA A 321 source : AC2 8) chain A residue 177 type sequence E description BINDING SITE FOR RESIDUE CA A 321 source : AC2 9) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE CA A 321 source : AC2 10) chain A residue 187 type sequence E description BINDING SITE FOR RESIDUE CA A 321 source : AC2 11) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE CA A 321 source : AC2 12) chain A residue 177 type sequence E description BINDING SITE FOR RESIDUE CA A 322 source : AC3 13) chain A residue 183 type sequence N description BINDING SITE FOR RESIDUE CA A 322 source : AC3 14) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE CA A 322 source : AC3 15) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE CA A 322 source : AC3 16) chain A residue 57 type sequence D description BINDING SITE FOR RESIDUE CA A 323 source : AC4 17) chain A residue 59 type sequence D description BINDING SITE FOR RESIDUE CA A 323 source : AC4 18) chain A residue 61 type sequence Q description BINDING SITE FOR RESIDUE CA A 323 source : AC4 19) chain A residue 193 type sequence Y description BINDING SITE FOR RESIDUE CA A 324 source : AC5 20) chain A residue 194 type sequence T description BINDING SITE FOR RESIDUE CA A 324 source : AC5 21) chain A residue 197 type sequence I description BINDING SITE FOR RESIDUE CA A 324 source : AC5 22) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE CA A 324 source : AC5 23) chain A residue 111 type sequence N description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 24) chain A residue 112 type sequence N description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 25) chain A residue 130 type sequence F description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 26) chain A residue 133 type sequence L description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 27) chain A residue 139 type sequence V description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 28) chain A residue 142 type sequence H description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 29) chain A residue 143 type sequence E description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 30) chain A residue 166 type sequence E description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 31) chain A residue 202 type sequence L description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 32) chain A residue 203 type sequence R description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 33) chain A residue 231 type sequence H description BINDING SITE FOR RESIDUE TI3 A 317 source : AC6 34) chain A residue 218 type sequence S description BINDING SITE FOR RESIDUE DMS A 325 source : AC7 35) chain A residue 251 type sequence Y description BINDING SITE FOR RESIDUE DMS A 325 source : AC7 36) chain A residue 115 type sequence W description BINDING SITE FOR RESIDUE DMS A 326 source : AC8 37) chain A residue 146 type sequence H description BINDING SITE FOR RESIDUE DMS A 326 source : AC8 38) chain A residue 151 type sequence Y description BINDING SITE FOR RESIDUE DMS A 327 source : AC9 39) chain A residue 291 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 40) chain A residue 289 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 41) chain A residue 293 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI1 42) chain A residue 139-148 type prosite sequence VVAHELTHAV description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV source prosite : PS00142

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