eF-site ID 1qco-AB PDB Code 1qco Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE Classification HYDROLASE Compound FUMARYLACETOACETATE HYDROLASE Source null (FAAA_MOUSE) Sequence A:  MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQI LDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKE ARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPAT IGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYH GRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMEL EMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQ QWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQD PKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFK HMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFG SMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDG YRVGFGQCAGKVLPALS B:  GSMSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGD QILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAW KEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLP ATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVG YHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDM ELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARD IQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPK QDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSN FKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPES FGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQG DGYRVGFGQCAGKVLPALS Description Functional site 1) chain B residue 626 type sequence D description BINDING SITE FOR RESIDUE CA B 1001 source : AC1 2) chain B residue 699 type sequence E description BINDING SITE FOR RESIDUE CA B 1001 source : AC1 3) chain B residue 701 type sequence E description BINDING SITE FOR RESIDUE CA B 1001 source : AC1 4) chain B residue 733 type sequence D description BINDING SITE FOR RESIDUE CA B 1001 source : AC1 5) chain A residue 126 type sequence D description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 6) chain A residue 199 type sequence E description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 7) chain A residue 201 type sequence E description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 8) chain A residue 233 type sequence D description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 9) chain B residue 654 type sequence H description BINDING SITE FOR RESIDUE NI B 1003 source : AC3 10) chain B residue 511 type sequence D description BINDING SITE FOR RESIDUE NI B 1004 source : AC4 11) chain B residue 895 type sequence H description BINDING SITE FOR RESIDUE NI B 1004 source : AC4 12) chain A residue 399 type sequence D description BINDING SITE FOR RESIDUE NI B 1005 source : AC5 13) chain B residue 722 type sequence H description BINDING SITE FOR RESIDUE NI B 1005 source : AC5 14) chain A residue 11 type sequence D description BINDING SITE FOR RESIDUE NI A 1006 source : AC6 15) chain A residue 395 type sequence H description BINDING SITE FOR RESIDUE NI A 1006 source : AC6 16) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE NI B 1007 source : AC7 17) chain B residue 499 type sequence G description BINDING SITE FOR RESIDUE NI B 1007 source : AC7 18) chain A residue 128 type sequence Y description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 19) chain A residue 137 type sequence V description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 20) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 21) chain A residue 240 type sequence Q description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 22) chain A residue 244 type sequence Y description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 23) chain B residue 746 type sequence P description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 24) chain A residue 246 type sequence P description BINDING SITE FOR RESIDUE FUM B 1009 source : AC9 25) chain B residue 628 type sequence Y description BINDING SITE FOR RESIDUE FUM B 1009 source : AC9 26) chain B residue 637 type sequence V description BINDING SITE FOR RESIDUE FUM B 1009 source : AC9 27) chain B residue 642 type sequence R description BINDING SITE FOR RESIDUE FUM B 1009 source : AC9 28) chain B residue 740 type sequence Q description BINDING SITE FOR RESIDUE FUM B 1009 source : AC9 29) chain B residue 744 type sequence Y description BINDING SITE FOR RESIDUE FUM B 1009 source : AC9 30) chain A residue 126 type sequence D description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 31) chain A residue 127 type sequence F description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 32) chain A residue 128 type sequence Y description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 33) chain A residue 133 type sequence H description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 34) chain A residue 159 type sequence Y description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 35) chain A residue 199 type sequence E description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 36) chain A residue 201 type sequence E description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 37) chain A residue 233 type sequence D description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 38) chain A residue 253 type sequence K description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 39) chain A residue 349 type sequence G description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 40) chain A residue 350 type sequence T description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 41) chain B residue 626 type sequence D description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 42) chain B residue 627 type sequence F description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 43) chain B residue 628 type sequence Y description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 44) chain B residue 633 type sequence H description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 45) chain B residue 659 type sequence Y description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 46) chain B residue 699 type sequence E description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 47) chain B residue 701 type sequence E description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 48) chain B residue 733 type sequence D description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 49) chain B residue 753 type sequence K description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 50) chain B residue 849 type sequence G description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 51) chain B residue 850 type sequence T description BINDING SITE FOR RESIDUE AAE B 1011 source : BC2 52) chain A residue 309 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P16930 source Swiss-Prot : SWS_FT_FI7 53) chain B residue 809 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P16930 source Swiss-Prot : SWS_FT_FI7 54) chain A residue 417 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P25093 source Swiss-Prot : SWS_FT_FI8 55) chain B residue 917 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P25093 source Swiss-Prot : SWS_FT_FI8 56) chain A residue 133 type ACT_SITE sequence H description Proton acceptor => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI1 57) chain B residue 633 type ACT_SITE sequence H description Proton acceptor => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 126 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 59) chain A residue 199 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 201 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 61) chain B residue 626 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 62) chain B residue 699 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 63) chain B residue 701 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 128 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 65) chain A residue 142 type BINDING sequence R description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 66) chain A residue 240 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 67) chain A residue 244 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 68) chain A residue 350 type BINDING sequence T description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 69) chain B residue 628 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 70) chain B residue 850 type BINDING sequence T description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 71) chain B residue 642 type BINDING sequence R description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 72) chain B residue 740 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 73) chain B residue 744 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 74) chain A residue 233 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 75) chain A residue 253 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 76) chain A residue 257 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 77) chain B residue 733 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 78) chain B residue 753 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 79) chain B residue 757 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 80) chain A residue 2 type MOD_RES sequence S description N-acetylserine => ECO:0000250|UniProtKB:P16930 source Swiss-Prot : SWS_FT_FI5 81) chain B residue 502 type MOD_RES sequence S description N-acetylserine => ECO:0000250|UniProtKB:P16930 source Swiss-Prot : SWS_FT_FI5 82) chain A residue 84 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI6 83) chain A residue 92 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI6 84) chain B residue 584 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI6 85) chain B residue 592 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI6 86) chain A residue 253 type catalytic sequence K description 180 source MCSA : MCSA1 87) chain A residue 126 type catalytic sequence D description 180 source MCSA : MCSA1 88) chain A residue 133 type catalytic sequence H description 180 source MCSA : MCSA1 89) chain A residue 199 type catalytic sequence E description 180 source MCSA : MCSA1 90) chain A residue 201 type catalytic sequence E description 180 source MCSA : MCSA1 91) chain A residue 233 type catalytic sequence D description 180 source MCSA : MCSA1 92) chain A residue 237 type catalytic sequence R description 180 source MCSA : MCSA1 93) chain A residue 240 type catalytic sequence Q description 180 source MCSA : MCSA1 94) chain A residue 257 type catalytic sequence T description 180 source MCSA : MCSA1 95) chain A residue 364 type catalytic sequence E description 180 source MCSA : MCSA1 96) chain B residue 753 type catalytic sequence K description 180 source MCSA : MCSA2 97) chain B residue 626 type catalytic sequence D description 180 source MCSA : MCSA2 98) chain B residue 633 type catalytic sequence H description 180 source MCSA : MCSA2 99) chain B residue 699 type catalytic sequence E description 180 source MCSA : MCSA2 100) chain B residue 701 type catalytic sequence E description 180 source MCSA : MCSA2 101) chain B residue 733 type catalytic sequence D description 180 source MCSA : MCSA2 102) chain B residue 737 type catalytic sequence R description 180 source MCSA : MCSA2 103) chain B residue 740 type catalytic sequence Q description 180 source MCSA : MCSA2 104) chain B residue 757 type catalytic sequence T description 180 source MCSA : MCSA2 105) chain B residue 864 type catalytic sequence E description 180 source MCSA : MCSA2

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