eF-site ID 1qco-A PDB Code 1qco Chain A click to enlarge Title CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE Classification HYDROLASE Compound FUMARYLACETOACETATE HYDROLASE Source Mus musculus (Mouse) (FAAA_MOUSE) Sequence A:  MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQI LDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKE ARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPAT IGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYH GRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMEL EMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQ QWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQD PKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFK HMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFG SMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDG YRVGFGQCAGKVLPALS Description Functional site 1) chain A residue 126 type sequence D description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 2) chain A residue 199 type sequence E description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 3) chain A residue 201 type sequence E description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 4) chain A residue 233 type sequence D description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 5) chain A residue 399 type sequence D description BINDING SITE FOR RESIDUE NI B 1005 source : AC5 6) chain A residue 11 type sequence D description BINDING SITE FOR RESIDUE NI A 1006 source : AC6 7) chain A residue 395 type sequence H description BINDING SITE FOR RESIDUE NI A 1006 source : AC6 8) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE NI B 1007 source : AC7 9) chain A residue 128 type sequence Y description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 10) chain A residue 137 type sequence V description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 11) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 12) chain A residue 240 type sequence Q description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 13) chain A residue 244 type sequence Y description BINDING SITE FOR RESIDUE FUM A 1008 source : AC8 14) chain A residue 246 type sequence P description BINDING SITE FOR RESIDUE FUM B 1009 source : AC9 15) chain A residue 126 type sequence D description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 16) chain A residue 127 type sequence F description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 17) chain A residue 128 type sequence Y description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 18) chain A residue 133 type sequence H description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 19) chain A residue 159 type sequence Y description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 20) chain A residue 199 type sequence E description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 21) chain A residue 201 type sequence E description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 22) chain A residue 233 type sequence D description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 23) chain A residue 253 type sequence K description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 24) chain A residue 349 type sequence G description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 25) chain A residue 350 type sequence T description BINDING SITE FOR RESIDUE AAE A 1010 source : BC1 26) chain A residue 126 type catalytic sequence D description 180 source MCSA : MCSA1 27) chain A residue 364 type catalytic sequence E description 180 source MCSA : MCSA1 28) chain A residue 133 type catalytic sequence H description 180 source MCSA : MCSA1 29) chain A residue 199 type catalytic sequence E description 180 source MCSA : MCSA1 30) chain A residue 201 type catalytic sequence E description 180 source MCSA : MCSA1 31) chain A residue 233 type catalytic sequence D description 180 source MCSA : MCSA1 32) chain A residue 237 type catalytic sequence R description 180 source MCSA : MCSA1 33) chain A residue 240 type catalytic sequence Q description 180 source MCSA : MCSA1 34) chain A residue 253 type catalytic sequence K description 180 source MCSA : MCSA1 35) chain A residue 257 type catalytic sequence T description 180 source MCSA : MCSA1 36) chain A residue 126 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 199 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 201 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 128 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 142 type BINDING sequence R description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 41) chain A residue 240 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 244 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 350 type BINDING sequence T description BINDING => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI3 44) chain A residue 309 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P16930 source Swiss-Prot : SWS_FT_FI7 45) chain A residue 417 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P25093 source Swiss-Prot : SWS_FT_FI8 46) chain A residue 133 type ACT_SITE sequence H description Proton acceptor => ECO:0000305|PubMed:10508789 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 84 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI6 48) chain A residue 92 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI6 49) chain A residue 233 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 50) chain A residue 253 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 51) chain A residue 257 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11154690 source Swiss-Prot : SWS_FT_FI4 52) chain A residue 2 type MOD_RES sequence S description N-acetylserine => ECO:0000250|UniProtKB:P16930 source Swiss-Prot : SWS_FT_FI5

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