eF-site ID 1qal-A
PDB Code 1qal
Chain A

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Title THE ACTIVE SITE BASE CONTROLS COFACTOR REACTIVITY IN ESCHERICHIA COLI AMINE OXIDASE : X-RAY CRYSTALLOGRAPHIC STUDIES WITH MUTATIONAL VARIANTS
Classification OXIDOREDUCTASE
Compound COPPER AMINE OXIDASE
Source Escherichia coli (strain K12) (AMO_ECOLI)
Sequence A:  MVPMDKTLKEFGADVQWDDYAQLFTLIKDGAYVKVKPGAQ
TAIVNGQPLALQVPVVMKDNKAWVSDTFINDVFQSGLDQT
FQVEKRPHPLNALTADEIKQAVEIVKASADFKPNTRFTEI
SLLPPDKEAVWAFALENKPVDQPRKADVIMLDGKHIIEAV
VDLQNNKLLSWQPIKDAHGMVLLDDFASVQNIINNSEEFA
AAVKKRGITDAKKVITTPLTVGYFDGKDGLKQDARLLKVI
SYLDVGDGNYWAHPIENLVAVVDLEQKKIVKIEEGPVVPV
PMTARPFDGRDRVAPAVKPMQIIEPEGKNYTITGDMIHWR
NWDFHLSMNSRVGPMISTVTYNDNGTKRKVMYEGSLGGMI
VPYGDPDIGWYFKAYLNSGDYGMGTLTSPIARGKDAPSNA
VLLNETIADYTGVPMEIPRAIAVFERYAGPEYKHQEMGQP
NVSTERRELVVRWISTVGNXDYIFDWIFHENGTIGIDAGA
TGIEAVKGVKAKTMHDETAKDDTRYGTLIDHNIVGTTHQH
IYNFRLDLDVDGENNSLVAMDPVVKPNTAGGPRTSTMQVN
QYNIGNEQDAAQKFDPGTIRLLSNPNKENRMGNPVSYQII
PYAGGTHPVAKGAQFAPDEWIYHRLSFMDKQLWVTRYHPG
ERFPEGKYPNRSTHDTGLGQYSKDNESLDNTDAVVWMTTG
TTHVARAEEWPIMPTEWVHTLLKPWNFFDETPTLGALKK
Description


Functional site

1) chain A
residue 524
type
sequence H
description BINDING SITE FOR RESIDUE CU A 801
source : AC1

2) chain A
residue 526
type
sequence H
description BINDING SITE FOR RESIDUE CU A 801
source : AC1

3) chain A
residue 689
type
sequence H
description BINDING SITE FOR RESIDUE CU A 801
source : AC1

4) chain A
residue 133
type
sequence K
description BINDING SITE FOR RESIDUE CA A 802
source : AC2

5) chain A
residue 533
type
sequence D
description BINDING SITE FOR RESIDUE CA A 802
source : AC2

6) chain A
residue 534
type
sequence L
description BINDING SITE FOR RESIDUE CA A 802
source : AC2

7) chain A
residue 535
type
sequence D
description BINDING SITE FOR RESIDUE CA A 802
source : AC2

8) chain A
residue 678
type
sequence D
description BINDING SITE FOR RESIDUE CA A 802
source : AC2

9) chain A
residue 679
type
sequence A
description BINDING SITE FOR RESIDUE CA A 802
source : AC2

10) chain A
residue 573
type
sequence E
description BINDING SITE FOR RESIDUE CA A 803
source : AC3

11) chain A
residue 667
type
sequence Y
description BINDING SITE FOR RESIDUE CA A 803
source : AC3

12) chain A
residue 670
type
sequence D
description BINDING SITE FOR RESIDUE CA A 803
source : AC3

13) chain A
residue 672
type
sequence E
description BINDING SITE FOR RESIDUE CA A 803
source : AC3

14) chain A
residue 369
type catalytic
sequence Y
description 864
source MCSA : MCSA1

15) chain A
residue 383
type catalytic
sequence N
description 864
source MCSA : MCSA1

16) chain A
residue 466
type catalytic
sequence X
description 864
source MCSA : MCSA1

17) chain A
residue 524
type catalytic
sequence H
description 864
source MCSA : MCSA1

18) chain A
residue 526
type catalytic
sequence H
description 864
source MCSA : MCSA1

19) chain A
residue 689
type catalytic
sequence H
description 864
source MCSA : MCSA1

20) chain A
residue 455-468
type prosite
sequence LVVRWISTVGNXDY
description COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. LVVrwisTvgNYDY
source prosite : PS01164

21) chain A
residue 684-697
type prosite
sequence TTGTTHVARAEEWP
description COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TtGttHVaraEEwP
source prosite : PS01165

22) chain A
residue 383
type ACT_SITE
sequence N
description Proton acceptor => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1OAC
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 679
type BINDING
sequence A
description
source Swiss-Prot : SWS_FT_FI10

24) chain A
residue 466
type MOD_RES
sequence X
description 2',4',5'-topaquinone => ECO:0000269|PubMed:10387067, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL
source Swiss-Prot : SWS_FT_FI11

25) chain A
residue 466
type ACT_SITE
sequence X
description Schiff-base intermediate with substrate; via topaquinone => ECO:0000269|PubMed:10387067, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:2WGQ, ECO:0007744|PDB:2WO0, ECO:0007744|PDB:2WOF
source Swiss-Prot : SWS_FT_FI2

26) chain A
residue 381
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:10576737, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z
source Swiss-Prot : SWS_FT_FI3

27) chain A
residue 463
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1SPU
source Swiss-Prot : SWS_FT_FI4

28) chain A
residue 524
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:1SPU, ECO:0007744|PDB:2W0Q, ECO:0007744|PDB:2WGQ, ECO:0007744|PDB:2WO0, ECO:0007744|PDB:2WOF, ECO:0007744|PDB:2WOH
source Swiss-Prot : SWS_FT_FI5

29) chain A
residue 526
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:1SPU, ECO:0007744|PDB:2W0Q, ECO:0007744|PDB:2WGQ, ECO:0007744|PDB:2WO0, ECO:0007744|PDB:2WOF, ECO:0007744|PDB:2WOH
source Swiss-Prot : SWS_FT_FI5

30) chain A
residue 689
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:1SPU, ECO:0007744|PDB:2W0Q, ECO:0007744|PDB:2WGQ, ECO:0007744|PDB:2WO0, ECO:0007744|PDB:2WOF, ECO:0007744|PDB:2WOH
source Swiss-Prot : SWS_FT_FI5

31) chain A
residue 533
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:Q43077
source Swiss-Prot : SWS_FT_FI6

32) chain A
residue 535
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:Q43077
source Swiss-Prot : SWS_FT_FI6

33) chain A
residue 678
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:Q43077
source Swiss-Prot : SWS_FT_FI6

34) chain A
residue 534
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:1SPU, ECO:0007744|PDB:2W0Q, ECO:0007744|PDB:2WGQ, ECO:0007744|PDB:2WOH
source Swiss-Prot : SWS_FT_FI7

35) chain A
residue 573
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:1SPU, ECO:0007744|PDB:2W0Q, ECO:0007744|PDB:2WGQ
source Swiss-Prot : SWS_FT_FI8

36) chain A
residue 667
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:1SPU, ECO:0007744|PDB:2W0Q, ECO:0007744|PDB:2WGQ
source Swiss-Prot : SWS_FT_FI8

37) chain A
residue 672
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544, ECO:0007744|PDB:1D6U, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1JRQ, ECO:0007744|PDB:1LVN, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAF, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:1SPU, ECO:0007744|PDB:2W0Q, ECO:0007744|PDB:2WGQ
source Swiss-Prot : SWS_FT_FI8

38) chain A
residue 670
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10576737, ECO:0007744|PDB:1D6Y, ECO:0007744|PDB:1D6Z, ECO:0007744|PDB:1DYU, ECO:0007744|PDB:1OAC, ECO:0007744|PDB:1QAK, ECO:0007744|PDB:1QAL, ECO:0007744|PDB:2WGQ
source Swiss-Prot : SWS_FT_FI9


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