eF-site ID 1qae-A PDB Code 1qae Chain A click to enlarge Title THE ACTIVE SITE OF SERRATIA ENDONUCLEASE CONTAINS A CONSERVED MAGNESIUM-WATER CLUSTER Classification ENDONUCLEASE Compound PROTEIN (EXTRACELLULAR ENDONUCLEASE) Source Serratia marcescens (NUCA_SERMA) Sequence A:  IDNCAVGCPTGGSSNVSIVRHAYTLNNNSTTKFANWVAYH ITKDTPASGKTRNWKTDPALNPADTLAPADYTGANAALKV DRGHQAPLASLAGVSDWESLNYLSNITPQKSDLNQGAWAR LEDQERKLIDRADISSVYTVTGPLYERDMGKLPGTQKAHT IPSAYWKVIFINNSPAVNHYAAFLFDQNTPKGADFCQFRV TVDEIEKRTGLIIWAGLPDDVQASLKSKPGVLPELMGCKN Description Functional site 1) chain A residue 89 type sequence H description ACTIVE SITE REGION IN MONOMER A WITH CATALYTIC MAGNESIUM WATER CLUSTER source : ASA 2) chain A residue 127 type sequence E description ACTIVE SITE REGION IN MONOMER A WITH CATALYTIC MAGNESIUM WATER CLUSTER source : ASA 3) chain A residue 119 type sequence N description ACTIVE SITE REGION IN MONOMER A WITH CATALYTIC MAGNESIUM WATER CLUSTER source : ASA 4) chain A residue 119 type sequence N description BINDING SITE FOR RESIDUE MG A 251 source : AC1 5) chain A residue 57 type catalytic sequence R description 42 source MCSA : MCSA1 6) chain A residue 89 type catalytic sequence H description 42 source MCSA : MCSA1 7) chain A residue 110 type catalytic sequence N description 42 source MCSA : MCSA1 8) chain A residue 119 type catalytic sequence N description 42 source MCSA : MCSA1 9) chain A residue 127 type catalytic sequence E description 42 source MCSA : MCSA1 10) chain A residue 86-94 type prosite sequence DRGHQAPLA description NUCLEASE_NON_SPEC DNA/RNA non-specific endonucleases active site. DRGHQaplA source prosite : PS01070 11) chain A residue 89 type ACT_SITE sequence H description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10047, ECO:0000269|PubMed:8078761 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 119 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2

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