eF-site ID 1q7b-ABCD PDB Code 1q7b Chain A, B, C, D click to enlarge Title The structure of betaketoacyl-[ACP] reductase from E. coli in complex with NADP+ Classification OXIDOREDUCTASE Compound 3-oxoacyl-[acyl-carrier protein] reductase Source Escherichia coli (strain K12) (FABG_ECOLI) Sequence A:  NFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENG AQAISDYLGANGKGLMLNVTDPASIESVLEKIRAEFGEVD ILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAV MRAMMKKRHGRIITIGSVVGTMGNGGQANYAAAKAGLIGF SKSLAREVASRGITVNVVAPGFIETDMTRALSDDQRAGIL AQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGM YMV B:  NFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENG AQAISDYLGANGKGLMLNVTDPASIESVLEKIRAEFGEVD ILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAV MRAMMKKRHGRIITIGSVVGTMGNGGQANYAAAKAGLIGF SKSLAREVASRGITVNVVAPGFIETDMTRSDDQRAGILAQ VPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGMYM V C:  NFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENG AQAISDYLGANGKGLMLNVTDPASIESVLEKIRAEFGEVD ILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAV MRAMMKKRHGRIITIGSVVGTMGNGGQANYAAAKAGLIGF SKSLAREVASRGITVNVVAPGFIETDMTRALSDDQRAGIL AQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGM YMV D:  NFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENG AQAISDYLGANGKGLMLNVTDPASIESVLEKIRAEFGEVD ILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAV MRAMMKKRHGRIITIGSVVGTMGNGGQANYAAAKAGLIGF SKSLAREVASRGITVNVVAPGFIETDMTRALSDDQRAGIL AQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGM YMV Description Functional site 1) chain B residue 233 type sequence E description BINDING SITE FOR RESIDUE CA B 9001 source : AC1 2) chain B residue 234 type sequence T description BINDING SITE FOR RESIDUE CA B 9001 source : AC1 3) chain C residue 233 type sequence E description BINDING SITE FOR RESIDUE CA B 9001 source : AC1 4) chain C residue 234 type sequence T description BINDING SITE FOR RESIDUE CA B 9001 source : AC1 5) chain A residue 233 type sequence E description BINDING SITE FOR RESIDUE CA A 9002 source : AC2 6) chain A residue 234 type sequence T description BINDING SITE FOR RESIDUE CA A 9002 source : AC2 7) chain D residue 233 type sequence E description BINDING SITE FOR RESIDUE CA A 9002 source : AC2 8) chain D residue 234 type sequence T description BINDING SITE FOR RESIDUE CA A 9002 source : AC2 9) chain B residue 50 type sequence G description BINDING SITE FOR RESIDUE CA B 9003 source : AC3 10) chain B residue 53 type sequence G description BINDING SITE FOR RESIDUE CA B 9003 source : AC3 11) chain C residue 145 type sequence N description BINDING SITE FOR RESIDUE CA C 9004 source : AC4 12) chain D residue 145 type sequence N description BINDING SITE FOR RESIDUE CA D 9005 source : AC5 13) chain A residue 145 type sequence N description BINDING SITE FOR RESIDUE CA A 9007 source : AC6 14) chain B residue 145 type sequence N description BINDING SITE FOR RESIDUE CA B 9008 source : AC7 15) chain A residue 12 type sequence G description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 16) chain A residue 14 type sequence S description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 17) chain A residue 15 type sequence R description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 18) chain A residue 17 type sequence I description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 19) chain A residue 37 type sequence T description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 20) chain A residue 58 type sequence L description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 21) chain A residue 59 type sequence N description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 22) chain A residue 60 type sequence V description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 23) chain A residue 86 type sequence N description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 24) chain A residue 87 type sequence A description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 25) chain A residue 88 type sequence G description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 26) chain A residue 89 type sequence I description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 27) chain A residue 136 type sequence I description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 28) chain A residue 137 type sequence G description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 29) chain A residue 138 type sequence S description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 30) chain A residue 151 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 31) chain A residue 155 type sequence K description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 32) chain A residue 181 type sequence P description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 33) chain A residue 182 type sequence G description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 34) chain A residue 184 type sequence I description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 35) chain A residue 186 type sequence T description BINDING SITE FOR RESIDUE NAP A 1901 source : AC8 36) chain B residue 12 type sequence G description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 37) chain B residue 14 type sequence S description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 38) chain B residue 15 type sequence R description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 39) chain B residue 17 type sequence I description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 40) chain B residue 36 type sequence A description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 41) chain B residue 37 type sequence T description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 42) chain B residue 58 type sequence L description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 43) chain B residue 59 type sequence N description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 44) chain B residue 60 type sequence V description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 45) chain B residue 86 type sequence N description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 46) chain B residue 87 type sequence A description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 47) chain B residue 88 type sequence G description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 48) chain B residue 136 type sequence I description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 49) chain B residue 137 type sequence G description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 50) chain B residue 138 type sequence S description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 51) chain B residue 151 type sequence Y description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 52) chain B residue 155 type sequence K description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 53) chain B residue 181 type sequence P description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 54) chain B residue 182 type sequence G description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 55) chain B residue 184 type sequence I description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 56) chain B residue 186 type sequence T description BINDING SITE FOR RESIDUE NAP B 2901 source : AC9 57) chain C residue 12 type sequence G description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 58) chain C residue 14 type sequence S description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 59) chain C residue 15 type sequence R description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 60) chain C residue 17 type sequence I description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 61) chain C residue 37 type sequence T description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 62) chain C residue 58 type sequence L description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 63) chain C residue 59 type sequence N description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 64) chain C residue 60 type sequence V description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 65) chain C residue 86 type sequence N description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 66) chain C residue 87 type sequence A description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 67) chain C residue 88 type sequence G description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 68) chain C residue 89 type sequence I description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 69) chain C residue 136 type sequence I description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 70) chain C residue 137 type sequence G description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 71) chain C residue 151 type sequence Y description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 72) chain C residue 155 type sequence K description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 73) chain C residue 181 type sequence P description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 74) chain C residue 182 type sequence G description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 75) chain C residue 184 type sequence I description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 76) chain C residue 186 type sequence T description BINDING SITE FOR RESIDUE NAP C 3901 source : BC1 77) chain D residue 12 type sequence G description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 78) chain D residue 14 type sequence S description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 79) chain D residue 15 type sequence R description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 80) chain D residue 36 type sequence A description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 81) chain D residue 37 type sequence T description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 82) chain D residue 58 type sequence L description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 83) chain D residue 59 type sequence N description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 84) chain D residue 60 type sequence V description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 85) chain D residue 86 type sequence N description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 86) chain D residue 87 type sequence A description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 87) chain D residue 88 type sequence G description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 88) chain D residue 89 type sequence I description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 89) chain D residue 136 type sequence I description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 90) chain D residue 137 type sequence G description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 91) chain D residue 138 type sequence S description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 92) chain D residue 151 type sequence Y description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 93) chain D residue 155 type sequence K description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 94) chain D residue 181 type sequence P description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 95) chain D residue 182 type sequence G description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 96) chain D residue 184 type sequence I description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 97) chain D residue 186 type sequence T description BINDING SITE FOR RESIDUE NAP D 4901 source : BC2 98) chain A residue 151 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 99) chain B residue 151 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 100) chain C residue 151 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 101) chain D residue 151 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 102) chain A residue 12 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 103) chain C residue 37 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 104) chain C residue 59 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 105) chain C residue 151 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 106) chain D residue 12 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 107) chain D residue 37 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 108) chain D residue 59 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 109) chain D residue 151 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 110) chain A residue 37 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 111) chain A residue 59 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 112) chain A residue 151 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 113) chain B residue 12 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 114) chain B residue 37 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 115) chain B residue 59 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 116) chain B residue 151 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 117) chain C residue 12 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C source Swiss-Prot : SWS_FT_FI2 118) chain A residue 138-166 type prosite sequence SVVGTMGNGGQANYAAAKAGLIGFSKSLA description ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgtmgnggQanYAAAKAGLiGFSkSLA source prosite : PS00061 119) chain A residue 50 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 120) chain B residue 234 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 121) chain C residue 50 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 122) chain C residue 53 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 123) chain C residue 145 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 124) chain C residue 233 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 125) chain C residue 234 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 126) chain D residue 50 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 127) chain D residue 53 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 128) chain D residue 145 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 129) chain D residue 233 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 130) chain A residue 53 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 131) chain D residue 234 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 132) chain A residue 145 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 133) chain A residue 233 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 134) chain A residue 234 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 135) chain B residue 50 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 136) chain B residue 53 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 137) chain B residue 145 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 138) chain B residue 233 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 139) chain A residue 86 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B source Swiss-Prot : SWS_FT_FI4 140) chain B residue 86 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B source Swiss-Prot : SWS_FT_FI4 141) chain C residue 86 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B source Swiss-Prot : SWS_FT_FI4 142) chain D residue 86 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B source Swiss-Prot : SWS_FT_FI4 143) chain A residue 138 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 144) chain B residue 138 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 145) chain C residue 138 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 146) chain D residue 138 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 147) chain A residue 184 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15016358 source Swiss-Prot : SWS_FT_FI6 148) chain B residue 184 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15016358 source Swiss-Prot : SWS_FT_FI6 149) chain C residue 184 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15016358 source Swiss-Prot : SWS_FT_FI6 150) chain D residue 184 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15016358 source Swiss-Prot : SWS_FT_FI6

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