eF-site ID 1q6x-A PDB Code 1q6x Chain A click to enlarge Title Crystal structure of rat choline acetyltransferase Classification TRANSFERASE Compound choline O-acetyltransferase Source Rattus norvegicus (Rat) (CLAT_RAT) Sequence A:  WEELDLPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAI VKRFGAPGGLGETLQEKLLERQEKTANWVSEYWLNDMYLN NRLALPVNSSPAVIFARQHFQDTNDQLRFAACLISGVLSY KTLLDSHSLPTDWAKGQLSGQPLCMKQYYRLFSSYRLPGH TQDTLVAQKSSIMPEPEHVIVACCNQFFVLDVVINFRRLS EGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAKAR TVLLKDSTNRDSLDMIERCICLVCLDGPGTGELSDTHRAL QLLHGGGCSLNGANRWYDKSLQFVVGRDGTCGVVCEHSPF DGIVLVQCTEHLLKHMMTSNKKLVRADSVSELPAPRRLRW KCSPETQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIK KQKYSPDGFIQVALQLAYYRLYQRLVPTYESASIRRFQEG RVDNIRSATPEALAFVQAMTDHKAAMPASEKLQLLQTAMQ AQTEYTVMAITGMAIDNHLLALRELARDLCKEPPEMFMDE TYLMSNRFVLSTSQVPTTMEMFCCYGPVVPNGYGACYNPQ PEAITFCISSFHSCKETSSVEFAEAVGASLVDMRDLCSSR Description Functional site 1) chain A residue 588 type sequence F description BINDING SITE FOR RESIDUE NA A 1002 source : AC2 2) chain A residue 589 type sequence H description BINDING SITE FOR RESIDUE NA A 1002 source : AC2 3) chain A residue 591 type sequence C description BINDING SITE FOR RESIDUE NA A 1002 source : AC2 4) chain A residue 594 type sequence T description BINDING SITE FOR RESIDUE NA A 1002 source : AC2 5) chain A residue 95 type catalytic sequence Y description 605 source MCSA : MCSA1 6) chain A residue 108 type catalytic sequence P description 605 source MCSA : MCSA1 7) chain A residue 334 type catalytic sequence H description 605 source MCSA : MCSA1 8) chain A residue 550 type catalytic sequence S description 605 source MCSA : MCSA1 9) chain A residue 412 type BINDING sequence G description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 450 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 551 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 334 type ACT_SITE sequence H description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 23-38 type prosite sequence LPKLPVPPLQQTLATY description ACYLTRANSF_C_1 Acyltransferases ChoActase / COT / CPT family signature 1. LPkLPVPpLqQTLatY source prosite : PS00439 14) chain A residue 312-339 type prosite sequence RWYDKSLQFVVGRDGTCGVVCEHSPFDG description ACYLTRANSF_C_2 Acyltransferases ChoActase / COT / CPT family signature 2. RWyDKsLqFVvgrDGtcgvvcEHspfDG source prosite : PS00440 15) chain A residue 365 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI4

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