eF-site ID 1q41-B PDB Code 1q41 Chain B click to enlarge Title GSK-3 Beta complexed with Indirubin-3'-monoxime Classification TRANSFERASE Compound GLYCOGEN SYNTHASE KINASE-3 BETA Source Homo sapiens (Human) (GSK3B_HUMAN) Sequence B:  SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK LCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY FFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL LEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF NFTTQELSSNPPLATILIPPHAR Description Functional site 1) chain B residue 62 type sequence I description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 2) chain B residue 83 type sequence A description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 3) chain B residue 133 type sequence D description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 4) chain B residue 134 type sequence Y description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 5) chain B residue 135 type sequence V description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 6) chain B residue 136 type sequence P description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 7) chain B residue 141 type sequence R description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 8) chain B residue 188 type sequence L description BINDING SITE FOR RESIDUE IXM B 452 source : AC2 9) chain B residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 10) chain B residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI5

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