eF-site ID 1pxi-A
PDB Code 1pxi
Chain A

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Title HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,5-Dichloro-thiophen-3-yl)-pyrimidin-2-ylamine
Classification TRANSFERASE
Compound Cell division protein kinase 2
Source Homo sapiens (Human) (CDK2_HUMAN)
Sequence A:  MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRTEGV
PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLH
QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV
TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP
GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWA
RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP
FFQDVTKPVPHLRL
Description


Functional site

1) chain A
residue 12
type
sequence E
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

2) chain A
residue 18
type
sequence V
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

3) chain A
residue 31
type
sequence A
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

4) chain A
residue 33
type
sequence K
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

5) chain A
residue 64
type
sequence V
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

6) chain A
residue 81
type
sequence E
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

7) chain A
residue 83
type
sequence L
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

8) chain A
residue 134
type
sequence L
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

9) chain A
residue 144
type
sequence A
description BINDING SITE FOR RESIDUE CK1 A 500
source : AC1

10) chain A
residue 127
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 10
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 33
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 81
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 86
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 129
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 132
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

17) chain A
residue 145
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

18) chain A
residue 9
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

19) chain A
residue 88
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

20) chain A
residue 166
type SITE
sequence L
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

21) chain A
residue 19
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:19369195
source Swiss-Prot : SWS_FT_FI9

22) chain A
residue 6
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI6

23) chain A
residue 14
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
source Swiss-Prot : SWS_FT_FI7

24) chain A
residue 15
type MOD_RES
sequence Y
description Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI8

25) chain A
residue 10-33
type prosite
sequence IGEGTYGVVYKARNKLTGEVVALK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
source prosite : PS00107

26) chain A
residue 123-135
type prosite
sequence VLHRDLKPQNLLI
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
source prosite : PS00108

27) chain A
residue 160
type MOD_RES
sequence T
description Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
source Swiss-Prot : SWS_FT_FI10

28) chain A
residue 1
type MOD_RES
sequence M
description N-acetylmethionine => ECO:0007744|PubMed:22814378
source Swiss-Prot : SWS_FT_FI5


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