eF-site ID 1pvq-AB PDB Code 1pvq Chain A, B click to enlarge Title BASIS FOR A SWITCH IN SUBSTRATE SPECIFICITY: CRYSTAL STRUCTURE OF SELECTED VARIANT OF CRE SITE-SPECIFIC RECOMBINASE, LNSGG BOUND TO THE ENGINEERED RECOGNITION SITE LOXM7 Classification RECOMBINATION/DNA Compound DNA 34-MER Source null (RECR_BPP1) Sequence A:  TSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKL NNRKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNML HRRSGLPRPSDSNAVSLVMRRIRKENVDAGERAKQALAFE RTDFDQVRSLMENSDRCQDIRNLAFLGIAYNTLLRLAEIA RIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVT KLVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSN SALGGIFGATHRLIYGAKDDSGQRYLAWSGHSARVGAARD MARAGVSIPEIMQAGGWTNVNIVMNYIRNLDSETGAMVRL LED B:  TSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKL NNRKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNML HRRSGLPRPSDSNAVSLVMRRIRKENVDAGERAKQALAFE RTDFDQVRSLMENSDRCQDIRNLAFLGIAYNTLLRLAEIA RIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVT KLVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSN SALGGIFGATHRLIYGAKDDSGQRYLAWSGHSARVGAARD MARAGVSIPEIMQAGGWTNVNIVMNYIRNTGAMVRLLED Description Functional site 1) chain A residue 173 type ACT_SITE sequence R description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 289 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 292 type ACT_SITE sequence R description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 315 type ACT_SITE sequence W description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 173 type ACT_SITE sequence R description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 289 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 7) chain B residue 292 type ACT_SITE sequence R description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 315 type ACT_SITE sequence W description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 324 type ACT_SITE sequence Y description O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 324 type ACT_SITE sequence Y description O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01246 source Swiss-Prot : SWS_FT_FI2

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