|
|
eF-site ID
|
1ppl-E |
|
PDB Code
|
1ppl |
|
Chain
|
E |
|
click to enlarge
|
|
|
Title
|
CRYSTALLOGRAPHIC ANALYSIS OF TRANSITION-STATE MIMICS BOUND TO PENICILLOPEPSIN: PHOSPHORUS-CONTAINING PEPTIDE ANALOGUES |
|
Classification
|
HYDROLASE/hydrolase inhibitor |
|
Compound
|
PENICILLOPEPSIN |
|
Source
|
(PENP_PENJA) |
|
|
Sequence
|
E: |
AASGVATNTPTANDEEYITPVTIGGTTLNLNFDTGSADLW
VFSTELPASQQSGHSVYNPSATGKELSGYTWSISYGDGSS
ASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDG
LLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQ
QPGVYDFGFIDSSKYTGSLTYTGVDNSQGFWSFNVDSYTA
GSQSGDGFSGIADTGTTLLLLDDSVVSQYYSQVSGAQQDS
NAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDG
STCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFA
PQA
|
|
|
Description
|
(1) |
PENICILLOPEPSIN
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
30-41 |
| type |
prosite |
| sequence |
LNFDTGSADLWV
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
|
| source |
prosite : PS00141
|
|
|
2)
|
chain |
E |
| residue |
210-221 |
| type |
prosite |
| sequence |
GIADTGTTLLLL
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
|
| source |
prosite : PS00141
|
|
|
3)
|
chain |
E |
| residue |
33 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
E |
| residue |
213 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
E |
| residue |
3 |
| type |
CARBOHYD |
| sequence |
S
|
| description |
O-linked (Man...) serine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
E |
| residue |
7 |
| type |
CARBOHYD |
| sequence |
T
|
| description |
O-linked (Man...) threonine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|