eF-site ID 1pke-A PDB Code 1pke Chain A click to enlarge Title Crystal Structure of E. coli purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine and sulfate/phosphate Classification TRANSFERASE Compound Purine nucleoside phosphorylase DeoD-type Source ORGANISM_SCIENTIFIC: Escherichia coli O157:H7; Sequence A:  ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVN NVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDF GVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRF KDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFY SPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTIC TVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK Description Functional site 1) chain A residue 20 type sequence G description BINDING SITE FOR RESIDUE PO4 A 449 source : AC1 2) chain A residue 43 type sequence R description BINDING SITE FOR RESIDUE PO4 A 449 source : AC1 3) chain A residue 87 type sequence R description BINDING SITE FOR RESIDUE PO4 A 449 source : AC1 4) chain A residue 89 type sequence G description BINDING SITE FOR RESIDUE PO4 A 449 source : AC1 5) chain A residue 90 type sequence S description BINDING SITE FOR RESIDUE PO4 A 449 source : AC1 6) chain A residue 4 type sequence H description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 7) chain A residue 43 type sequence R description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 8) chain A residue 90 type sequence S description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 9) chain A residue 91 type sequence C description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 10) chain A residue 92 type sequence G description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 11) chain A residue 159 type sequence F description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 12) chain A residue 178 type sequence V description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 13) chain A residue 179 type sequence E description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 14) chain A residue 180 type sequence M description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 15) chain A residue 181 type sequence E description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 16) chain A residue 204 type sequence D description BINDING SITE FOR RESIDUE 2FD A 446 source : AC2 17) chain A residue 204 type ACT_SITE sequence D description Proton donor => ECO:0000255|HAMAP-Rule:MF_01627 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 4 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12937174 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 43 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12937174 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 20 type BINDING sequence G description in other chain => ECO:0000269|PubMed:12937174 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 24 type BINDING sequence R description in other chain => ECO:0000269|PubMed:12937174 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 87 type BINDING sequence R description in other chain => ECO:0000269|PubMed:12937174 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 179 type BINDING sequence E description in other chain => ECO:0000269|PubMed:12937174 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 203 type BINDING sequence S description in other chain => ECO:0000269|PubMed:12937174 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 217 type SITE sequence R description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 26 type MOD_RES sequence K description N6-acetyllysine => ECO:0000255|HAMAP-Rule:MF_01627 source Swiss-Prot : SWS_FT_FI5 27) chain A residue 61-76 type prosite sequence GHGMGIPSCSIYTKEL description PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiPScSIytkEL source prosite : PS01232

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