eF-site ID 1pkd-ABCD
PDB Code 1pkd
Chain A, B, C, D

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Title THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO-CDK2/CYCLIN A
Classification TRANSFERASE/CELL CYCLE
Compound Cell division protein kinase 2
Source Homo sapiens (Human) (CCNA2_HUMAN)
Sequence A:  SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT
ETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLV
FEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH
SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY
XHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTR
RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS
FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA
ALAHPFFQDVTKPVPHL
B:  VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL
VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ
LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM
FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNL
C:  SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT
ETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLV
FEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH
SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY
XHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTR
RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS
FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA
ALAHPFFQDVTKPVPHL
D:  VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL
VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ
LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM
FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNL
Description


Functional site

1) chain A
residue 10
type
sequence I
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

2) chain A
residue 11
type
sequence G
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

3) chain A
residue 31
type
sequence A
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

4) chain A
residue 33
type
sequence K
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

5) chain A
residue 64
type
sequence V
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

6) chain A
residue 80
type
sequence F
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

7) chain A
residue 81
type
sequence E
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

8) chain A
residue 82
type
sequence F
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

9) chain A
residue 83
type
sequence L
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

10) chain A
residue 84
type
sequence H
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

11) chain A
residue 86
type
sequence D
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

12) chain A
residue 131
type
sequence Q
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

13) chain A
residue 132
type
sequence N
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

14) chain A
residue 134
type
sequence L
description BINDING SITE FOR RESIDUE UCN A 410
source : AC1

15) chain C
residue 10
type
sequence I
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

16) chain C
residue 11
type
sequence G
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

17) chain C
residue 18
type
sequence V
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

18) chain C
residue 31
type
sequence A
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

19) chain C
residue 33
type
sequence K
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

20) chain C
residue 64
type
sequence V
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

21) chain C
residue 80
type
sequence F
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

22) chain C
residue 81
type
sequence E
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

23) chain C
residue 82
type
sequence F
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

24) chain C
residue 83
type
sequence L
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

25) chain C
residue 84
type
sequence H
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

26) chain C
residue 131
type
sequence Q
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

27) chain C
residue 132
type
sequence N
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

28) chain C
residue 134
type
sequence L
description BINDING SITE FOR RESIDUE UCN C 411
source : AC2

29) chain A
residue 127
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

30) chain C
residue 127
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 10
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

32) chain C
residue 129
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

33) chain A
residue 33
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

34) chain A
residue 81
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

35) chain A
residue 86
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

36) chain A
residue 129
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

37) chain C
residue 10
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

38) chain C
residue 33
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

39) chain C
residue 81
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

40) chain C
residue 86
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

41) chain A
residue 160
type MOD_RES
sequence X
description Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
source Swiss-Prot : SWS_FT_FI10

42) chain C
residue 160
type MOD_RES
sequence X
description Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
source Swiss-Prot : SWS_FT_FI10

43) chain A
residue 132
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

44) chain A
residue 145
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

45) chain C
residue 132
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

46) chain C
residue 145
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

47) chain A
residue 15
type MOD_RES
sequence Y
description Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI8

48) chain C
residue 15
type MOD_RES
sequence Y
description Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI8

49) chain A
residue 19
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:19369195
source Swiss-Prot : SWS_FT_FI9

50) chain C
residue 19
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:19369195
source Swiss-Prot : SWS_FT_FI9

51) chain A
residue 10-33
type prosite
sequence IGEGTYGVVYKARNKLTGEVVALK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
source prosite : PS00107

52) chain A
residue 123-135
type prosite
sequence VLHRDLKPQNLLI
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
source prosite : PS00108

53) chain B
residue 211-242
type prosite
sequence RAILVDWLVEVGEEYKLQNETLHLAVNYIDRF
description CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
source prosite : PS00292

54) chain A
residue 9
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

55) chain A
residue 88
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

56) chain A
residue 166
type SITE
sequence L
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

57) chain C
residue 9
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

58) chain C
residue 88
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

59) chain C
residue 166
type SITE
sequence L
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

60) chain A
residue 1
type MOD_RES
sequence M
description N-acetylmethionine => ECO:0007744|PubMed:22814378
source Swiss-Prot : SWS_FT_FI5

61) chain C
residue 1
type MOD_RES
sequence M
description N-acetylmethionine => ECO:0007744|PubMed:22814378
source Swiss-Prot : SWS_FT_FI5

62) chain A
residue 6
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI6

63) chain C
residue 6
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI6

64) chain A
residue 14
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
source Swiss-Prot : SWS_FT_FI7

65) chain C
residue 14
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
source Swiss-Prot : SWS_FT_FI7


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