eF-site ID 1pjs-B PDB Code 1pjs Chain B click to enlarge Title The co-crystal structure of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis, in complex with it NAD cofactor Classification TRANSFERASE/OXIDOREDUCTASE/LYASE Compound Siroheme synthase Source null (CYSG_SALTY) Sequence B:  MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTV NALTFIPQFTVWANEGMLTLVEGPFDETLLDSCWLAIAAT DDDTVNQRVSDAAESRRIFCNVVDAPKAASFIMPSIIDRS PLMVAVSXGGTSPVLARLLREKLESLLPQHLGQVARYAGQ LRARVKKQFATMGERRRFWEKFFVNDRLAQSLANADEKAV NATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQ QADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQE EINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHA GIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHG GELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADM PVALVENGTSVKQRVVHGVLTQLGELAQQVESPALIIVGR VVALRDKLNWFSNH Description Functional site 1) chain B residue 115 type sequence S description BINDING SITE FOR RESIDUE PO4 B 507 source : AC1 2) chain B residue 137 type sequence R description BINDING SITE FOR RESIDUE PO4 B 507 source : AC1 3) chain B residue 140 type sequence R description BINDING SITE FOR RESIDUE PO4 B 507 source : AC1 4) chain B residue 225 type sequence P description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 5) chain B residue 301 type sequence G description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 6) chain B residue 302 type sequence G description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 7) chain B residue 303 type sequence D description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 8) chain B residue 306 type sequence I description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 9) chain B residue 307 type sequence F description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 10) chain B residue 331 type sequence T description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 11) chain B residue 332 type sequence A description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 12) chain B residue 336 type sequence C description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 13) chain B residue 381 type sequence Y description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 14) chain B residue 382 type sequence M description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 15) chain B residue 408 type sequence V description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 16) chain B residue 410 type sequence N description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 17) chain B residue 411 type sequence G description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 18) chain B residue 436 type sequence P description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 19) chain B residue 437 type sequence A description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 20) chain B residue 438 type sequence L description BINDING SITE FOR RESIDUE SAH B 503 source : AC4 21) chain B residue 20 type sequence G description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 22) chain B residue 21 type sequence G description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 23) chain B residue 22 type sequence D description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 24) chain B residue 23 type sequence V description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 25) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 26) chain B residue 43 type sequence L description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 27) chain B residue 44 type sequence T description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 28) chain B residue 80 type sequence T description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 29) chain B residue 81 type sequence D description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 30) chain B residue 85 type sequence V description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 31) chain B residue 104 type sequence D description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 32) chain B residue 281 type sequence E description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 33) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 34) chain B residue 292 type sequence K description BINDING SITE FOR RESIDUE NAD B 504 source : AC5 35) chain B residue 241 type sequence Q description BINDING SITE FOR RESIDUE PGE A 505 source : AC6 36) chain B residue 139 type sequence L description BINDING SITE FOR RESIDUE PGE A 506 source : AC7 37) chain B residue 248 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 270 type ACT_SITE sequence K description Proton donor => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 22 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 40) chain B residue 43 type BINDING sequence L description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 225 type BINDING sequence P description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 42) chain B residue 301 type BINDING sequence G description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 43) chain B residue 306 type BINDING sequence I description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 44) chain B residue 331 type BINDING sequence T description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 45) chain B residue 382 type BINDING sequence M description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 46) chain B residue 411 type BINDING sequence G description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 47) chain B residue 437 type BINDING sequence A description BINDING => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI3 48) chain B residue 128 type MOD_RES sequence X description Phosphoserine => ECO:0000269|PubMed:14595395 source Swiss-Prot : SWS_FT_FI4 49) chain B residue 248 type catalytic sequence D description 702 source MCSA : MCSA2 50) chain B residue 270 type catalytic sequence K description 702 source MCSA : MCSA2 51) chain B residue 382 type catalytic sequence M description 702 source MCSA : MCSA2

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