eF-site ID 1pek-E PDB Code 1pek Chain E click to enlarge Title STRUCTURE OF THE COMPLEX OF PROTEINASE K WITH A SUBSTRATE-ANALOGUE HEXA-PEPTIDE INHIBITOR AT 2.2 ANGSTROMS RESOLUTION Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEINASE K Source ORGANISM_COMMON: Engyodontium album; ORGANISM_SCIENTIFIC: Tritirachium album; Sequence E:  AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDT GIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSR TYGVVKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNN RNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAG NNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLD IFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTL GKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA Description (1)  PROTEINASE K (E.C.3.4.21.64) COMPLEX WITH N-AC-PRO-ALA-PRO-PHE-D-ALA-ALA-NH2 (A SUBSTRATE ANALOGUE) Functional site 1) chain E residue 39 type sequence D description source : ACT 2) chain E residue 69 type sequence H description source : ACT 3) chain E residue 224 type sequence S description source : ACT 4) chain E residue 69 type sequence H description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 5) chain E residue 96 type sequence L description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 6) chain E residue 100 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 7) chain E residue 132 type sequence S description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 8) chain E residue 133 type sequence L description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 9) chain E residue 134 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 10) chain E residue 135 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 11) chain E residue 158 type sequence A description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 12) chain E residue 160 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 13) chain E residue 161 type sequence N description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 14) chain E residue 224 type sequence S description BINDING SITE FOR CHAIN C OF PEPTIDE PRO-ALA-PRO-PHE source : AC1 15) chain E residue 69 type sequence H description BINDING SITE FOR CHAIN D OF D-DAL-ALA-NH2 source : AC2 16) chain E residue 161 type sequence N description BINDING SITE FOR CHAIN D OF D-DAL-ALA-NH2 source : AC2 17) chain E residue 220 type sequence I description BINDING SITE FOR CHAIN D OF D-DAL-ALA-NH2 source : AC2 18) chain E residue 221 type sequence S description BINDING SITE FOR CHAIN D OF D-DAL-ALA-NH2 source : AC2 19) chain E residue 222 type sequence G description BINDING SITE FOR CHAIN D OF D-DAL-ALA-NH2 source : AC2 20) chain E residue 223 type sequence T description BINDING SITE FOR CHAIN D OF D-DAL-ALA-NH2 source : AC2 21) chain E residue 224 type sequence S description BINDING SITE FOR CHAIN D OF D-DAL-ALA-NH2 source : AC2 22) chain E residue 39 type ACT_SITE sequence D description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 23) chain E residue 69 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 24) chain E residue 224 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 25) chain E residue 35-46 type prosite sequence VYVIDTGIEASH description SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VYVIDTGIeasH source prosite : PS00136 26) chain E residue 69-79 type prosite sequence HGTHCAGTVGS description SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThCAGtVGS source prosite : PS00137 27) chain E residue 222-232 type prosite sequence GTSMATPHVAG description SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAtPhVAG source prosite : PS00138 28) chain E residue 175 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 29) chain E residue 177 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 30) chain E residue 200 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 31) chain E residue 260 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 32) chain E residue 16 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2

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