eF-site ID 1pe0-A
PDB Code 1pe0
Chain A

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Title Crystal structure of the K130R mutant of human DJ-1
Classification PROTEIN BINDING
Compound DJ-1
Source Homo sapiens (Human) (PARK7_HUMAN)
Sequence A:  ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGK
DPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQN
LSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGS
KVTTHPLARDKMMNGGHYTYSENRVEKDGLILTSRGPGTS
FEFALAIVEALNGKEVAAQVKAPLVLK
Description


Functional site

1) chain A
residue 106
type ACT_SITE
sequence C
description Nucleophile => ECO:0000305|PubMed:20304780, ECO:0000305|PubMed:25416785
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 126
type ACT_SITE
sequence H
description ACT_SITE => ECO:0000305|PubMed:20304780
source Swiss-Prot : SWS_FT_FI2

3) chain A
residue 130
type CROSSLNK
sequence R
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15976810
source Swiss-Prot : SWS_FT_FI11

4) chain A
residue 149
type SITE
sequence D
description Cleavage; by CASP6 => ECO:0000250|UniProtKB:Q99LX0
source Swiss-Prot : SWS_FT_FI3

5) chain A
residue 2
type MOD_RES
sequence A
description N-acetylalanine => ECO:0007744|PubMed:25944712
source Swiss-Prot : SWS_FT_FI4

6) chain A
residue 67
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:15592455
source Swiss-Prot : SWS_FT_FI5

7) chain A
residue 106
type MOD_RES
sequence C
description Cysteine sulfinic acid (-SO2H); alternate => ECO:0000269|PubMed:12939276
source Swiss-Prot : SWS_FT_FI6

8) chain A
residue 148
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:Q99LX0
source Swiss-Prot : SWS_FT_FI7

9) chain A
residue 182
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:Q99LX0
source Swiss-Prot : SWS_FT_FI8

10) chain A
residue 46
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000269|PubMed:23847046
source Swiss-Prot : SWS_FT_FI9

11) chain A
residue 53
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000269|PubMed:23847046
source Swiss-Prot : SWS_FT_FI9

12) chain A
residue 106
type LIPID
sequence C
description S-palmitoyl cysteine; alternate => ECO:0000269|PubMed:23847046
source Swiss-Prot : SWS_FT_FI10


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