eF-site/Summary 1pe0-B

eF-site ID	1pe0-B
PDB Code	1pe0
Chain	B

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Title	Crystal structure of the K130R mutant of human DJ-1
Classification	PROTEIN BINDING
Compound	DJ-1
Source	Homo sapiens (Human) (PARK7_HUMAN)

Sequence	B:	ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGK DPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQN LSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGS KVTTHPLARDKMMNGGHYTYSENRVEKDGLILTSRGPGTS FEFALAIVEALNGKEVAAQVKAPLVLK

Description

Functional site


1)	chain	B
	residue	306
	type	ACT_SITE
	sequence	C
	description	Nucleophile => ECO:0000305\|PubMed:20304780, ECO:0000305\|PubMed:25416785
	source	Swiss-Prot : SWS_FT_FI1

2)	chain	B
	residue	326
	type	ACT_SITE
	sequence	H
	description	ACT_SITE => ECO:0000305\|PubMed:20304780
	source	Swiss-Prot : SWS_FT_FI2

3)	chain	B
	residue	330
	type	CROSSLNK
	sequence	R
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269\|PubMed:15976810
	source	Swiss-Prot : SWS_FT_FI11

4)	chain	B
	residue	349
	type	SITE
	sequence	D
	description	Cleavage; by CASP6 => ECO:0000250\|UniProtKB:Q99LX0
	source	Swiss-Prot : SWS_FT_FI3

5)	chain	B
	residue	202
	type	MOD_RES
	sequence	A
	description	N-acetylalanine => ECO:0007744\|PubMed:25944712
	source	Swiss-Prot : SWS_FT_FI4

6)	chain	B
	residue	267
	type	MOD_RES
	sequence	Y
	description	Phosphotyrosine => ECO:0007744\|PubMed:15592455
	source	Swiss-Prot : SWS_FT_FI5

7)	chain	B
	residue	306
	type	MOD_RES
	sequence	C
	description	Cysteine sulfinic acid (-SO2H); alternate => ECO:0000269\|PubMed:12939276
	source	Swiss-Prot : SWS_FT_FI6

8)	chain	B
	residue	348
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0000250\|UniProtKB:Q99LX0
	source	Swiss-Prot : SWS_FT_FI7

9)	chain	B
	residue	382
	type	MOD_RES
	sequence	K
	description	N6-succinyllysine => ECO:0000250\|UniProtKB:Q99LX0
	source	Swiss-Prot : SWS_FT_FI8

10)	chain	B
	residue	246
	type	LIPID
	sequence	C
	description	S-palmitoyl cysteine => ECO:0000269\|PubMed:23847046
	source	Swiss-Prot : SWS_FT_FI9

11)	chain	B
	residue	253
	type	LIPID
	sequence	C
	description	S-palmitoyl cysteine => ECO:0000269\|PubMed:23847046
	source	Swiss-Prot : SWS_FT_FI9

12)	chain	B
	residue	306
	type	LIPID
	sequence	C
	description	S-palmitoyl cysteine; alternate => ECO:0000269\|PubMed:23847046
	source	Swiss-Prot : SWS_FT_FI10