eF-site ID 1p6m-AB PDB Code 1p6m Chain A, B click to enlarge Title Bovine endothelial NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound Classification OXIDOREDUCTASE Compound Nitric-oxide synthase, endothelial Source null (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPRAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAE VASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVF DARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAP GRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQ HGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLE HPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGW YMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKD KAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQK ARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQ PDPW B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVA STGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDA RDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHG WTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHP TLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKA AVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKAR GGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD PW Description Functional site 1) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE CAC A 850 source : AC1 2) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE CAC A 850 source : AC1 3) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 4) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 5) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAC B 852 source : AC3 6) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAC B 852 source : AC3 7) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAC B 852 source : AC3 8) chain B residue 190 type sequence I description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 9) chain B residue 191 type sequence Q description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 10) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 11) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 12) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 13) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 14) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 15) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 16) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : AC5 17) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 18) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 19) chain A residue 187 type sequence V description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 20) chain A residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 21) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 22) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 23) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 24) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 25) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 26) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 500 source : AC6 27) chain A residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 28) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 29) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 30) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 31) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 32) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 33) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 34) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 35) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 36) chain B residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 37) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE DP3 A 793 source : AC8 38) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE DP3 A 793 source : AC8 39) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE DP3 A 793 source : AC8 40) chain A residue 357 type sequence G description BINDING SITE FOR RESIDUE DP3 A 793 source : AC8 41) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE DP3 A 793 source : AC8 42) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE DP3 A 793 source : AC8 43) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 44) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 45) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 46) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 47) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 48) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 49) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 50) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 51) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 52) chain B residue 475 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 53) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC9 54) chain A residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 55) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 56) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 57) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 58) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 59) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 60) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 61) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 62) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 63) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 64) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 65) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 66) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 67) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE DP3 B 794 source : BC2 68) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL A 880 source : BC3 69) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL A 880 source : BC3 70) chain A residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL A 880 source : BC3 71) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL B 882 source : BC4 72) chain A residue 463 type sequence H description BINDING SITE FOR RESIDUE GOL B 882 source : BC4 73) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 882 source : BC4 74) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 882 source : BC4 75) chain A residue 187 type BINDING sequence V description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 76) chain B residue 187 type BINDING sequence V description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 77) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 78) chain A residue 97 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 102 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 80) chain B residue 97 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 102 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 82) chain A residue 105 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 83) chain A residue 250 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 84) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 85) chain B residue 105 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 86) chain B residue 250 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 87) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 88) chain B residue 360 type BINDING sequence M description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 89) chain B residue 364 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 90) chain B residue 369 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 91) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 450 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 463 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 95) chain A residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 96) chain A residue 360 type BINDING sequence M description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 97) chain A residue 364 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 98) chain A residue 369 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 99) chain A residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 100) chain A residue 450 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 101) chain A residue 463 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2

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