eF-site ID 1p6j-AB
PDB Code 1p6j
Chain A, B

click to enlarge
Title Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound
Classification OXIDOREDUCTASE
Compound Nitric-oxide synthase, brain
Source Rattus norvegicus (Rat) (NOS1_RAT)
Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP
TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE
STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA
RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK
HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG
WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP
KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM
GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA
LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR
GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD
PWNTHVW
B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP
VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE
IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF
DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD
GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ
QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR
HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW
YMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKD
QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR
CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ
PDPWNTHVWK
Description


Functional site

1) chain A
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE ACT A 860
source : AC1

2) chain A
residue 657
type
sequence S
description BINDING SITE FOR RESIDUE ACT A 860
source : AC1

3) chain B
residue 417
type
sequence G
description BINDING SITE FOR RESIDUE ACT B 861
source : AC2

4) chain B
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE ACT B 861
source : AC2

5) chain B
residue 649
type
sequence V
description BINDING SITE FOR RESIDUE ACT B 861
source : AC2

6) chain A
residue 326
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC3

7) chain A
residue 331
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC3

8) chain B
residue 326
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC3

9) chain B
residue 331
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC3

10) chain A
residue 409
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

11) chain A
residue 415
type
sequence C
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

12) chain A
residue 416
type
sequence V
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

13) chain A
residue 457
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

14) chain A
residue 584
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

15) chain A
residue 585
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

16) chain A
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

17) chain A
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

18) chain A
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

19) chain A
residue 706
type
sequence Y
description BINDING SITE FOR RESIDUE HEM A 750
source : AC4

20) chain A
residue 334
type
sequence S
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

21) chain A
residue 596
type
sequence R
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

22) chain A
residue 677
type
sequence V
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

23) chain A
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

24) chain B
residue 676
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

25) chain B
residue 691
type
sequence F
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

26) chain B
residue 692
type
sequence H
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

27) chain B
residue 693
type
sequence Q
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

28) chain B
residue 694
type
sequence E
description BINDING SITE FOR RESIDUE H4B A 760
source : AC5

29) chain A
residue 478
type
sequence Q
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

30) chain A
residue 565
type
sequence P
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

31) chain A
residue 567
type
sequence V
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

32) chain A
residue 585
type
sequence S
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

33) chain A
residue 586
type
sequence G
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

34) chain A
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

35) chain A
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

36) chain A
residue 706
type
sequence Y
description BINDING SITE FOR RESIDUE DP9 A 799
source : AC6

37) chain B
residue 409
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

38) chain B
residue 414
type
sequence R
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

39) chain B
residue 415
type
sequence C
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

40) chain B
residue 457
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

41) chain B
residue 584
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

42) chain B
residue 585
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

43) chain B
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

44) chain B
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

45) chain B
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

46) chain B
residue 706
type
sequence Y
description BINDING SITE FOR RESIDUE HEM B 750
source : AC7

47) chain A
residue 676
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

48) chain A
residue 691
type
sequence F
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

49) chain A
residue 692
type
sequence H
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

50) chain A
residue 694
type
sequence E
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

51) chain B
residue 334
type
sequence S
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

52) chain B
residue 596
type
sequence R
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

53) chain B
residue 677
type
sequence V
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

54) chain B
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 761
source : AC8

55) chain B
residue 478
type
sequence Q
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

56) chain B
residue 565
type
sequence P
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

57) chain B
residue 567
type
sequence V
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

58) chain B
residue 585
type
sequence S
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

59) chain B
residue 586
type
sequence G
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

60) chain B
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

61) chain B
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

62) chain B
residue 706
type
sequence Y
description BINDING SITE FOR RESIDUE DP9 B 800
source : AC9

63) chain A
residue 334
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

64) chain B
residue 334
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

65) chain B
residue 478
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

66) chain B
residue 587
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

67) chain B
residue 588
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

68) chain B
residue 592
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

69) chain B
residue 677
type BINDING
sequence V
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

70) chain B
residue 678
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

71) chain B
residue 691
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

72) chain B
residue 706
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

73) chain A
residue 478
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

74) chain A
residue 587
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

75) chain A
residue 588
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

76) chain A
residue 592
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

77) chain A
residue 677
type BINDING
sequence V
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

78) chain A
residue 678
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

79) chain A
residue 691
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

80) chain A
residue 706
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

81) chain A
residue 414-421
type prosite
sequence RCVGRIQW
description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW
source prosite : PS60001

82) chain A
residue 415
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI2

83) chain B
residue 415
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI2


Display surface

Download
Links