eF-site ID 1p33-C PDB Code 1p33 Chain C click to enlarge Title Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX Classification OXIDOREDUCTASE Compound Pteridine reductase 1 Source Leishmania tarentolae (Sauroleishmania tarentolae) (PTR1_LEITA) Sequence C:  PTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAAD ASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRC SALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVAA ADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMV DAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVN GVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDV VIFLCSPKAKYITGTCIKVDGGYSLTRA Description Functional site 1) chain C residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 2) chain C residue 15 type sequence A description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 3) chain C residue 17 type sequence R description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 4) chain C residue 18 type sequence L description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 5) chain C residue 37 type sequence Y description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 6) chain C residue 38 type sequence H description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 7) chain C residue 39 type sequence R description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 8) chain C residue 40 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 9) chain C residue 65 type sequence D description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 10) chain C residue 66 type sequence L description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 11) chain C residue 67 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 12) chain C residue 109 type sequence N description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 13) chain C residue 110 type sequence A description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 14) chain C residue 111 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 15) chain C residue 112 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 16) chain C residue 142 type sequence D description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 17) chain C residue 146 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 18) chain C residue 179 type sequence M description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 19) chain C residue 180 type sequence V description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 20) chain C residue 194 type sequence Y description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 21) chain C residue 198 type sequence K description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 22) chain C residue 224 type sequence P description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 23) chain C residue 225 type sequence G description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 24) chain C residue 226 type sequence L description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 25) chain C residue 227 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 26) chain C residue 228 type sequence V description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 27) chain C residue 17 type sequence R description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 28) chain C residue 111 type sequence S description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 29) chain C residue 113 type sequence F description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 30) chain C residue 115 type sequence P description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 31) chain C residue 181 type sequence D description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 32) chain C residue 188 type sequence L description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 33) chain C residue 191 type sequence Y description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 34) chain C residue 194 type sequence Y description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 35) chain C residue 226 type sequence L description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 36) chain C residue 229 type sequence L description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 37) chain C residue 230 type sequence P description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 38) chain C residue 233 type sequence M description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 39) chain C residue 241 type sequence Y description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 40) chain C residue 194 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 41) chain C residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 42) chain C residue 194 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 43) chain C residue 175 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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