eF-site ID 1p33-B PDB Code 1p33 Chain B click to enlarge Title Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX Classification OXIDOREDUCTASE Compound Pteridine reductase 1 Source null (PTR1_LEITA) Sequence B:  SPTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAA DASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSR CSALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVA AADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNM VDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRV NGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSD VVIFLCSPKAKYITGTCIKVDGGYSLTRA Description Functional site 1) chain B residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 2) chain B residue 16 type sequence K description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 3) chain B residue 17 type sequence R description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 4) chain B residue 18 type sequence L description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 5) chain B residue 36 type sequence H description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 6) chain B residue 38 type sequence H description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 7) chain B residue 39 type sequence R description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 8) chain B residue 40 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 9) chain B residue 64 type sequence A description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 10) chain B residue 65 type sequence D description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 11) chain B residue 66 type sequence L description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 12) chain B residue 67 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 13) chain B residue 109 type sequence N description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 14) chain B residue 110 type sequence A description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 15) chain B residue 111 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 16) chain B residue 112 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 17) chain B residue 142 type sequence D description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 18) chain B residue 179 type sequence M description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 19) chain B residue 180 type sequence V description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 20) chain B residue 194 type sequence Y description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 21) chain B residue 198 type sequence K description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 22) chain B residue 224 type sequence P description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 23) chain B residue 225 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 24) chain B residue 227 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 25) chain B residue 228 type sequence V description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 26) chain B residue 17 type sequence R description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 27) chain B residue 111 type sequence S description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 28) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 29) chain B residue 115 type sequence P description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 30) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 31) chain B residue 188 type sequence L description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 32) chain B residue 191 type sequence Y description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 33) chain B residue 194 type sequence Y description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 34) chain B residue 226 type sequence L description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 35) chain B residue 230 type sequence P description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 36) chain B residue 233 type sequence M description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 37) chain B residue 241 type sequence Y description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 38) chain B residue 194 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 194 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 175 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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