eF-site ID 1p33-ABCD
PDB Code 1p33
Chain A, B, C, D

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Title Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX
Classification OXIDOREDUCTASE
Compound Pteridine reductase 1
Source Leishmania tarentolae (Sauroleishmania tarentolae) (PTR1_LEITA)
Sequence A:  TAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADA
STLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCS
ALVDACYMHWGRCDVLVNNASSFYPTPLLRDKESLEVAAA
DLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVD
AMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNG
VSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDVV
IFLCSPKAKYITGTCIKVDGGYSLTRA
B:  SPTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAA
DASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSR
CSALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVA
AADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNM
VDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRV
NGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSD
VVIFLCSPKAKYITGTCIKVDGGYSLTRA
C:  PTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAAD
ASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRC
SALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVAA
ADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMV
DAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVN
GVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDV
VIFLCSPKAKYITGTCIKVDGGYSLTRA
D:  TAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADA
STLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCS
ALVDACYMHWGRCDVLVNNASSFYPTPLLRKDKESLEVAA
ADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMV
DAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVN
GVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDV
VIFLCSPKAKYITGTCIKVDGGYSLTRA
Description


Functional site

1) chain A
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

2) chain A
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

3) chain A
residue 18
type
sequence L
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

4) chain A
residue 38
type
sequence H
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

5) chain A
residue 39
type
sequence R
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

6) chain A
residue 40
type
sequence S
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

7) chain A
residue 64
type
sequence A
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

8) chain A
residue 65
type
sequence D
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

9) chain A
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

10) chain A
residue 67
type
sequence S
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

11) chain A
residue 109
type
sequence N
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

12) chain A
residue 110
type
sequence A
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

13) chain A
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

14) chain A
residue 112
type
sequence S
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

15) chain A
residue 142
type
sequence D
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

16) chain A
residue 179
type
sequence M
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

17) chain A
residue 180
type
sequence V
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

18) chain A
residue 181
type
sequence D
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

19) chain A
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

20) chain A
residue 198
type
sequence K
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

21) chain A
residue 224
type
sequence P
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

22) chain A
residue 225
type
sequence G
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

23) chain A
residue 226
type
sequence L
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

24) chain A
residue 227
type
sequence S
description BINDING SITE FOR RESIDUE NDP A 300
source : AC1

25) chain B
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

26) chain B
residue 16
type
sequence K
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

27) chain B
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

28) chain B
residue 18
type
sequence L
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

29) chain B
residue 36
type
sequence H
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

30) chain B
residue 38
type
sequence H
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

31) chain B
residue 39
type
sequence R
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

32) chain B
residue 40
type
sequence S
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

33) chain B
residue 64
type
sequence A
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

34) chain B
residue 65
type
sequence D
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

35) chain B
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

36) chain B
residue 67
type
sequence S
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

37) chain B
residue 109
type
sequence N
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

38) chain B
residue 110
type
sequence A
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

39) chain B
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

40) chain B
residue 112
type
sequence S
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

41) chain B
residue 142
type
sequence D
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

42) chain B
residue 179
type
sequence M
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

43) chain B
residue 180
type
sequence V
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

44) chain B
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

45) chain B
residue 198
type
sequence K
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

46) chain B
residue 224
type
sequence P
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

47) chain B
residue 225
type
sequence G
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

48) chain B
residue 227
type
sequence S
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

49) chain B
residue 228
type
sequence V
description BINDING SITE FOR RESIDUE NDP B 301
source : AC2

50) chain C
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

51) chain C
residue 15
type
sequence A
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

52) chain C
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

53) chain C
residue 18
type
sequence L
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

54) chain C
residue 37
type
sequence Y
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

55) chain C
residue 38
type
sequence H
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

56) chain C
residue 39
type
sequence R
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

57) chain C
residue 40
type
sequence S
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

58) chain C
residue 65
type
sequence D
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

59) chain C
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

60) chain C
residue 67
type
sequence S
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

61) chain C
residue 109
type
sequence N
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

62) chain C
residue 110
type
sequence A
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

63) chain C
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

64) chain C
residue 112
type
sequence S
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

65) chain C
residue 142
type
sequence D
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

66) chain C
residue 146
type
sequence S
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

67) chain C
residue 179
type
sequence M
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

68) chain C
residue 180
type
sequence V
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

69) chain C
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

70) chain C
residue 198
type
sequence K
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

71) chain C
residue 224
type
sequence P
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

72) chain C
residue 225
type
sequence G
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

73) chain C
residue 226
type
sequence L
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

74) chain C
residue 227
type
sequence S
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

75) chain C
residue 228
type
sequence V
description BINDING SITE FOR RESIDUE NDP C 302
source : AC3

76) chain D
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

77) chain D
residue 15
type
sequence A
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

78) chain D
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

79) chain D
residue 18
type
sequence L
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

80) chain D
residue 38
type
sequence H
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

81) chain D
residue 39
type
sequence R
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

82) chain D
residue 40
type
sequence S
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

83) chain D
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

84) chain D
residue 67
type
sequence S
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

85) chain D
residue 109
type
sequence N
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

86) chain D
residue 110
type
sequence A
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

87) chain D
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

88) chain D
residue 112
type
sequence S
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

89) chain D
residue 142
type
sequence D
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

90) chain D
residue 179
type
sequence M
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

91) chain D
residue 180
type
sequence V
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

92) chain D
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

93) chain D
residue 198
type
sequence K
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

94) chain D
residue 224
type
sequence P
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

95) chain D
residue 225
type
sequence G
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

96) chain D
residue 227
type
sequence S
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

97) chain D
residue 228
type
sequence V
description BINDING SITE FOR RESIDUE NDP D 303
source : AC4

98) chain A
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

99) chain A
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

100) chain A
residue 113
type
sequence F
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

101) chain A
residue 115
type
sequence P
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

102) chain A
residue 181
type
sequence D
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

103) chain A
residue 188
type
sequence L
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

104) chain A
residue 191
type
sequence Y
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

105) chain A
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

106) chain A
residue 226
type
sequence L
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

107) chain A
residue 229
type
sequence L
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

108) chain A
residue 230
type
sequence P
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

109) chain A
residue 241
type
sequence Y
description BINDING SITE FOR RESIDUE MTX A 351
source : AC5

110) chain B
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

111) chain B
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

112) chain B
residue 113
type
sequence F
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

113) chain B
residue 115
type
sequence P
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

114) chain B
residue 181
type
sequence D
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

115) chain B
residue 188
type
sequence L
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

116) chain B
residue 191
type
sequence Y
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

117) chain B
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

118) chain B
residue 226
type
sequence L
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

119) chain B
residue 230
type
sequence P
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

120) chain B
residue 233
type
sequence M
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

121) chain B
residue 241
type
sequence Y
description BINDING SITE FOR RESIDUE MTX B 352
source : AC6

122) chain C
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

123) chain C
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

124) chain C
residue 113
type
sequence F
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

125) chain C
residue 115
type
sequence P
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

126) chain C
residue 181
type
sequence D
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

127) chain C
residue 188
type
sequence L
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

128) chain C
residue 191
type
sequence Y
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

129) chain C
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

130) chain C
residue 226
type
sequence L
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

131) chain C
residue 229
type
sequence L
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

132) chain C
residue 230
type
sequence P
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

133) chain C
residue 233
type
sequence M
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

134) chain C
residue 241
type
sequence Y
description BINDING SITE FOR RESIDUE MTX C 353
source : AC7

135) chain D
residue 17
type
sequence R
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

136) chain D
residue 111
type
sequence S
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

137) chain D
residue 113
type
sequence F
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

138) chain D
residue 115
type
sequence P
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

139) chain D
residue 181
type
sequence D
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

140) chain D
residue 191
type
sequence Y
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

141) chain D
residue 194
type
sequence Y
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

142) chain D
residue 229
type
sequence L
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

143) chain D
residue 230
type
sequence P
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

144) chain D
residue 233
type
sequence M
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

145) chain D
residue 241
type
sequence Y
description BINDING SITE FOR RESIDUE MTX D 354
source : AC8

146) chain A
residue 181-209
type prosite
sequence DAMTSQPLLGYTMYTMAKEALEGLTRSAA
description ADH_SHORT Short-chain dehydrogenases/reductases family signature. DamtsqpllgYtmYTMAKEALeGLTrSAA
source prosite : PS00061

147) chain A
residue 194
type ACT_SITE
sequence Y
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
source Swiss-Prot : SWS_FT_FI1

148) chain B
residue 194
type ACT_SITE
sequence Y
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
source Swiss-Prot : SWS_FT_FI1

149) chain C
residue 194
type ACT_SITE
sequence Y
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
source Swiss-Prot : SWS_FT_FI1

150) chain D
residue 194
type ACT_SITE
sequence Y
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
source Swiss-Prot : SWS_FT_FI1

151) chain A
residue 13
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

152) chain A
residue 194
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

153) chain B
residue 13
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

154) chain B
residue 194
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

155) chain C
residue 13
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

156) chain C
residue 194
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

157) chain D
residue 13
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

158) chain D
residue 194
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12925782
source Swiss-Prot : SWS_FT_FI2

159) chain A
residue 175
type BINDING
sequence S
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

160) chain B
residue 175
type BINDING
sequence S
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

161) chain C
residue 175
type BINDING
sequence S
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

162) chain D
residue 175
type BINDING
sequence S
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3


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