eF-site ID 1p33-ABCD PDB Code 1p33 Chain A, B, C, D click to enlarge Title Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX Classification OXIDOREDUCTASE Compound Pteridine reductase 1 Source Leishmania tarentolae (Sauroleishmania tarentolae) (PTR1_LEITA) Sequence A:  TAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADA STLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCS ALVDACYMHWGRCDVLVNNASSFYPTPLLRDKESLEVAAA DLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVD AMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNG VSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDVV IFLCSPKAKYITGTCIKVDGGYSLTRA B:  SPTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAA DASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSR CSALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVA AADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNM VDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRV NGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSD VVIFLCSPKAKYITGTCIKVDGGYSLTRA C:  PTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAAD ASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRC SALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVAA ADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMV DAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVN GVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDV VIFLCSPKAKYITGTCIKVDGGYSLTRA D:  TAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADA STLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCS ALVDACYMHWGRCDVLVNNASSFYPTPLLRKDKESLEVAA ADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMV DAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVN GVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDV VIFLCSPKAKYITGTCIKVDGGYSLTRA Description Functional site 1) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 2) chain A residue 17 type sequence R description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 3) chain A residue 18 type sequence L description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 4) chain A residue 38 type sequence H description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 5) chain A residue 39 type sequence R description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 6) chain A residue 40 type sequence S description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 7) chain A residue 64 type sequence A description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 8) chain A residue 65 type sequence D description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 9) chain A residue 66 type sequence L description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 10) chain A residue 67 type sequence S description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 11) chain A residue 109 type sequence N description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 12) chain A residue 110 type sequence A description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 13) chain A residue 111 type sequence S description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 14) chain A residue 112 type sequence S description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 15) chain A residue 142 type sequence D description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 16) chain A residue 179 type sequence M description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 17) chain A residue 180 type sequence V description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 18) chain A residue 181 type sequence D description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 19) chain A residue 194 type sequence Y description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 20) chain A residue 198 type sequence K description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 21) chain A residue 224 type sequence P description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 22) chain A residue 225 type sequence G description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 23) chain A residue 226 type sequence L description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 24) chain A residue 227 type sequence S description BINDING SITE FOR RESIDUE NDP A 300 source : AC1 25) chain B residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 26) chain B residue 16 type sequence K description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 27) chain B residue 17 type sequence R description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 28) chain B residue 18 type sequence L description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 29) chain B residue 36 type sequence H description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 30) chain B residue 38 type sequence H description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 31) chain B residue 39 type sequence R description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 32) chain B residue 40 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 33) chain B residue 64 type sequence A description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 34) chain B residue 65 type sequence D description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 35) chain B residue 66 type sequence L description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 36) chain B residue 67 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 37) chain B residue 109 type sequence N description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 38) chain B residue 110 type sequence A description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 39) chain B residue 111 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 40) chain B residue 112 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 41) chain B residue 142 type sequence D description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 42) chain B residue 179 type sequence M description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 43) chain B residue 180 type sequence V description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 44) chain B residue 194 type sequence Y description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 45) chain B residue 198 type sequence K description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 46) chain B residue 224 type sequence P description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 47) chain B residue 225 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 48) chain B residue 227 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 49) chain B residue 228 type sequence V description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 50) chain C residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 51) chain C residue 15 type sequence A description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 52) chain C residue 17 type sequence R description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 53) chain C residue 18 type sequence L description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 54) chain C residue 37 type sequence Y description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 55) chain C residue 38 type sequence H description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 56) chain C residue 39 type sequence R description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 57) chain C residue 40 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 58) chain C residue 65 type sequence D description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 59) chain C residue 66 type sequence L description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 60) chain C residue 67 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 61) chain C residue 109 type sequence N description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 62) chain C residue 110 type sequence A description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 63) chain C residue 111 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 64) chain C residue 112 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 65) chain C residue 142 type sequence D description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 66) chain C residue 146 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 67) chain C residue 179 type sequence M description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 68) chain C residue 180 type sequence V description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 69) chain C residue 194 type sequence Y description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 70) chain C residue 198 type sequence K description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 71) chain C residue 224 type sequence P description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 72) chain C residue 225 type sequence G description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 73) chain C residue 226 type sequence L description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 74) chain C residue 227 type sequence S description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 75) chain C residue 228 type sequence V description BINDING SITE FOR RESIDUE NDP C 302 source : AC3 76) chain D residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 77) chain D residue 15 type sequence A description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 78) chain D residue 17 type sequence R description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 79) chain D residue 18 type sequence L description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 80) chain D residue 38 type sequence H description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 81) chain D residue 39 type sequence R description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 82) chain D residue 40 type sequence S description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 83) chain D residue 66 type sequence L description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 84) chain D residue 67 type sequence S description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 85) chain D residue 109 type sequence N description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 86) chain D residue 110 type sequence A description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 87) chain D residue 111 type sequence S description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 88) chain D residue 112 type sequence S description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 89) chain D residue 142 type sequence D description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 90) chain D residue 179 type sequence M description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 91) chain D residue 180 type sequence V description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 92) chain D residue 194 type sequence Y description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 93) chain D residue 198 type sequence K description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 94) chain D residue 224 type sequence P description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 95) chain D residue 225 type sequence G description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 96) chain D residue 227 type sequence S description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 97) chain D residue 228 type sequence V description BINDING SITE FOR RESIDUE NDP D 303 source : AC4 98) chain A residue 17 type sequence R description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 99) chain A residue 111 type sequence S description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 100) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 101) chain A residue 115 type sequence P description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 102) chain A residue 181 type sequence D description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 103) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 104) chain A residue 191 type sequence Y description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 105) chain A residue 194 type sequence Y description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 106) chain A residue 226 type sequence L description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 107) chain A residue 229 type sequence L description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 108) chain A residue 230 type sequence P description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 109) chain A residue 241 type sequence Y description BINDING SITE FOR RESIDUE MTX A 351 source : AC5 110) chain B residue 17 type sequence R description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 111) chain B residue 111 type sequence S description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 112) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 113) chain B residue 115 type sequence P description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 114) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 115) chain B residue 188 type sequence L description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 116) chain B residue 191 type sequence Y description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 117) chain B residue 194 type sequence Y description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 118) chain B residue 226 type sequence L description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 119) chain B residue 230 type sequence P description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 120) chain B residue 233 type sequence M description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 121) chain B residue 241 type sequence Y description BINDING SITE FOR RESIDUE MTX B 352 source : AC6 122) chain C residue 17 type sequence R description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 123) chain C residue 111 type sequence S description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 124) chain C residue 113 type sequence F description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 125) chain C residue 115 type sequence P description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 126) chain C residue 181 type sequence D description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 127) chain C residue 188 type sequence L description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 128) chain C residue 191 type sequence Y description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 129) chain C residue 194 type sequence Y description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 130) chain C residue 226 type sequence L description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 131) chain C residue 229 type sequence L description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 132) chain C residue 230 type sequence P description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 133) chain C residue 233 type sequence M description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 134) chain C residue 241 type sequence Y description BINDING SITE FOR RESIDUE MTX C 353 source : AC7 135) chain D residue 17 type sequence R description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 136) chain D residue 111 type sequence S description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 137) chain D residue 113 type sequence F description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 138) chain D residue 115 type sequence P description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 139) chain D residue 181 type sequence D description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 140) chain D residue 191 type sequence Y description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 141) chain D residue 194 type sequence Y description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 142) chain D residue 229 type sequence L description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 143) chain D residue 230 type sequence P description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 144) chain D residue 233 type sequence M description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 145) chain D residue 241 type sequence Y description BINDING SITE FOR RESIDUE MTX D 354 source : AC8 146) chain A residue 181-209 type prosite sequence DAMTSQPLLGYTMYTMAKEALEGLTRSAA description ADH_SHORT Short-chain dehydrogenases/reductases family signature. DamtsqpllgYtmYTMAKEALeGLTrSAA source prosite : PS00061 147) chain A residue 194 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 148) chain B residue 194 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 149) chain C residue 194 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 150) chain D residue 194 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 151) chain A residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 152) chain A residue 194 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 153) chain B residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 154) chain B residue 194 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 155) chain C residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 156) chain C residue 194 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 157) chain D residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 158) chain D residue 194 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12925782 source Swiss-Prot : SWS_FT_FI2 159) chain A residue 175 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 160) chain B residue 175 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 161) chain C residue 175 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 162) chain D residue 175 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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