eF-site ID 1p12-E PDB Code 1p12 Chain E click to enlarge Title CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS Classification HYDROLASE/HYDROLASE INHIBITOR Compound ALPHA-LYTIC PROTEASE Source null (1P12) Sequence E:  ANIVGGIEYSINNASLCSVGFSVTRGATKGFVTAGHCGTV NATARIGGAVVGTFAARVFPGNDRAWVSLTSAQTLLPRVA NGSSFVTVRGSTEAAVGAAVCRSGRTTGYQCGTITAKNVT ANYAEGAVRGLTQGNACMGRGDSGGSWITSAGQAQGVMSG GNVQSNGNNCGIPASQRSSLFERLQPILSQYGLSLVTG Description Functional site 1) chain E residue 230 type sequence R description BINDING SITE FOR RESIDUE SO4 E 1 source : AC1 2) chain E residue 233 type sequence P description BINDING SITE FOR RESIDUE SO4 E 1 source : AC1 3) chain E residue 40 type sequence S description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 4) chain E residue 41 type sequence L description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 5) chain E residue 42 type sequence C description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 6) chain E residue 57 type sequence H description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 7) chain E residue 125 type sequence R description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 8) chain E residue 128 type sequence T description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 9) chain E residue 171 type sequence Y description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 10) chain E residue 174 type sequence E description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 11) chain E residue 192 type sequence M description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 12) chain E residue 192 type sequence M description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 13) chain E residue 193 type sequence G description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 14) chain E residue 194 type sequence D description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 15) chain E residue 195 type sequence S description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 16) chain E residue 208 type sequence Q description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 17) chain E residue 214 type sequence S description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 18) chain E residue 215 type sequence G description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 19) chain E residue 216 type sequence G description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 20) chain E residue 217 type sequence N description BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR source : AC2 21) chain E residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain E residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 23) chain E residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 24) chain E residue 57 type catalytic sequence H description 609 source MCSA : MCSA1 25) chain E residue 102 type catalytic sequence D description 609 source MCSA : MCSA1 26) chain E residue 193 type catalytic sequence G description 609 source MCSA : MCSA1 27) chain E residue 195 type catalytic sequence S description 609 source MCSA : MCSA1 28) chain E residue 214 type catalytic sequence S description 609 source MCSA : MCSA1 29) chain E residue 53-58 type prosite sequence VTAGHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC source prosite : PS00134 30) chain E residue 191-200 type prosite sequence CMGRGDSGGSWI description TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI source prosite : PS00135

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