eF-site ID 1oyp-ABCDEF PDB Code 1oyp Chain A, B, C, D, E, F click to enlarge Title Crystal Structure of the phosphorolytic exoribonuclease RNase PH from Bacillus subtilis Classification TRANSFERASE Compound Ribonuclease PH Source ORGANISM_SCIENTIFIC: Bacillus subtilis; Sequence A:  MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICN ASVEDRVPPFLRGGGKGWITAEYSMLSGRTMEIQRLIGRA LRAVVDLEKLGERTIWIDCDVIQADGGTRTASITGAFLAM AIAIGKLIKAGTIKTNPITDFLAAISVGIDKEQGILLDLN YEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNG LLGLAEKGIQELIDKQKEVLGDSLPE B:  MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICN ASVEDRVPPFLRGGGKGWITAEYSMLSGRTMEIQRLIGRA LRAVVDLEKLGERTIWIDCDVIQADGGTRTASITGAFLAM AIAIGKLIKAGTIKTNPITDFLAAISVGIDKEQGILLDLN YEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNG LLGLAEKGIQELIDKQKEVLGDSLPE C:  MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICN ASVEDRVPPFLRGGGKGWITAEYSMLSGRTMEIQRLIGRA LRAVVDLEKLGERTIWIDCDVIQADGGTRTASITGAFLAM AIAIGKLIKAGTIKTNPITDFLAAISVGIDKEQGILLDLN YEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNG LLGLAEKGIQELIDKQKEVLGDSLPE D:  MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICN ASVEDRVPPFLRGGGKGWITAEYSMLSGRTMEIQRLIGRA LRAVVDLEKLGERTIWIDCDVIQADGGTRTASITGAFLAM AIAIGKLIKAGTIKTNPITDFLAAISVGIDKEQGILLDLN YEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNG LLGLAEKGIQELIDKQKEVLGDSLPE E:  MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICN ASVEDRVPPFLRGGGKGWITAEYSMLSGRTMEIQRLIGRA LRAVVDLEKLGERTIWIDCDVIQADGGTRTASITGAFLAM AIAIGKLIKAGTIKTNPITDFLAAISVGIDKEQGILLDLN YEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNG LLGLAEKGIQELIDKQKEVLGDSLPE F:  MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICN ASVEDRVPPFLRGGGKGWITAEYSMLSGRTMEIQRLIGRA LRAVVDLEKLGERTIWIDCDVIQADGGTRTASITGAFLAM AIAIGKLIKAGTIKTNPITDFLAAISVGIDKEQGILLDLN YEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNG LLGLAEKGIQELIDKQKEVLGDSLPE Description Functional site 1) chain A residue 86 type sequence R description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 2) chain A residue 124 type sequence G description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 3) chain A residue 125 type sequence T description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 4) chain A residue 126 type sequence R description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 5) chain A residue 58 type sequence W description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 6) chain A residue 60 type sequence T description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 7) chain A residue 99 type sequence R description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 8) chain B residue 86 type sequence R description BINDING SITE FOR RESIDUE SO4 B 303 source : AC3 9) chain B residue 124 type sequence G description BINDING SITE FOR RESIDUE SO4 B 303 source : AC3 10) chain B residue 125 type sequence T description BINDING SITE FOR RESIDUE SO4 B 303 source : AC3 11) chain B residue 126 type sequence R description BINDING SITE FOR RESIDUE SO4 B 303 source : AC3 12) chain B residue 58 type sequence W description BINDING SITE FOR RESIDUE SO4 B 304 source : AC4 13) chain B residue 60 type sequence T description BINDING SITE FOR RESIDUE SO4 B 304 source : AC4 14) chain B residue 99 type sequence R description BINDING SITE FOR RESIDUE SO4 B 304 source : AC4 15) chain C residue 86 type sequence R description BINDING SITE FOR RESIDUE SO4 C 305 source : AC5 16) chain C residue 124 type sequence G description BINDING SITE FOR RESIDUE SO4 C 305 source : AC5 17) chain C residue 125 type sequence T description BINDING SITE FOR RESIDUE SO4 C 305 source : AC5 18) chain C residue 126 type sequence R description BINDING SITE FOR RESIDUE SO4 C 305 source : AC5 19) chain C residue 58 type sequence W description BINDING SITE FOR RESIDUE SO4 C 306 source : AC6 20) chain C residue 60 type sequence T description BINDING SITE FOR RESIDUE SO4 C 306 source : AC6 21) chain C residue 99 type sequence R description BINDING SITE FOR RESIDUE SO4 C 306 source : AC6 22) chain D residue 86 type sequence R description BINDING SITE FOR RESIDUE SO4 D 307 source : AC7 23) chain D residue 124 type sequence G description BINDING SITE FOR RESIDUE SO4 D 307 source : AC7 24) chain D residue 125 type sequence T description BINDING SITE FOR RESIDUE SO4 D 307 source : AC7 25) chain D residue 126 type sequence R description BINDING SITE FOR RESIDUE SO4 D 307 source : AC7 26) chain D residue 58 type sequence W description BINDING SITE FOR RESIDUE SO4 D 308 source : AC8 27) chain D residue 60 type sequence T description BINDING SITE FOR RESIDUE SO4 D 308 source : AC8 28) chain D residue 99 type sequence R description BINDING SITE FOR RESIDUE SO4 D 308 source : AC8 29) chain E residue 86 type sequence R description BINDING SITE FOR RESIDUE SO4 E 309 source : AC9 30) chain E residue 124 type sequence G description BINDING SITE FOR RESIDUE SO4 E 309 source : AC9 31) chain E residue 125 type sequence T description BINDING SITE FOR RESIDUE SO4 E 309 source : AC9 32) chain E residue 126 type sequence R description BINDING SITE FOR RESIDUE SO4 E 309 source : AC9 33) chain E residue 58 type sequence W description BINDING SITE FOR RESIDUE SO4 E 310 source : BC1 34) chain E residue 60 type sequence T description BINDING SITE FOR RESIDUE SO4 E 310 source : BC1 35) chain E residue 99 type sequence R description BINDING SITE FOR RESIDUE SO4 E 310 source : BC1 36) chain F residue 86 type sequence R description BINDING SITE FOR RESIDUE SO4 F 311 source : BC2 37) chain F residue 124 type sequence G description BINDING SITE FOR RESIDUE SO4 F 311 source : BC2 38) chain F residue 125 type sequence T description BINDING SITE FOR RESIDUE SO4 F 311 source : BC2 39) chain F residue 126 type sequence R description BINDING SITE FOR RESIDUE SO4 F 311 source : BC2 40) chain F residue 58 type sequence W description BINDING SITE FOR RESIDUE SO4 F 312 source : BC3 41) chain F residue 60 type sequence T description BINDING SITE FOR RESIDUE SO4 F 312 source : BC3 42) chain F residue 99 type sequence R description BINDING SITE FOR RESIDUE SO4 F 312 source : BC3 43) chain A residue 86 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00564 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 86 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00564 source Swiss-Prot : SWS_FT_FI1 45) chain C residue 86 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00564 source Swiss-Prot : SWS_FT_FI1 46) chain D residue 86 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00564 source Swiss-Prot : SWS_FT_FI1 47) chain E residue 86 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00564 source Swiss-Prot : SWS_FT_FI1 48) chain F residue 86 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00564 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 116-128 type prosite sequence CDVIQADGGTRTA description RIBONUCLEASE_PH Ribonuclease PH signature. CDVIQADGGtr.TA source prosite : PS01277 50) chain A residue 124 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00564, ECO:0000305|PubMed:14767080 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 124 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00564, ECO:0000305|PubMed:14767080 source Swiss-Prot : SWS_FT_FI2 52) chain C residue 124 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00564, ECO:0000305|PubMed:14767080 source Swiss-Prot : SWS_FT_FI2 53) chain D residue 124 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00564, ECO:0000305|PubMed:14767080 source Swiss-Prot : SWS_FT_FI2 54) chain E residue 124 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00564, ECO:0000305|PubMed:14767080 source Swiss-Prot : SWS_FT_FI2 55) chain F residue 124 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00564, ECO:0000305|PubMed:14767080 source Swiss-Prot : SWS_FT_FI2

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