eF-site ID 1owe-A PDB Code 1owe Chain A click to enlarge Title Substituted 2-Naphthamidine inhibitors of urokinase Classification HYDROLASE Compound Urokinase-type plasminogen activator Source null (UROK_HUMAN) Sequence A:  IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCW VISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVEN LILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTI CLPSMYNDPQFGTSCEITGFGKEQSTDYLYPEQLKMTVVK LISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPW IRSHT Description (1)  Urokinase-type plasminogen activator (E.C.3.4.21.73) Functional site 1) chain A residue 61 type sequence K description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 2) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 3) chain A residue 191 type sequence T description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 4) chain A residue 193 type sequence K description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 5) chain A residue 194 type sequence M description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 6) chain A residue 32 type sequence V description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 7) chain A residue 34 type sequence C description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 8) chain A residue 54 type sequence H description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 9) chain A residue 208 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 10) chain A residue 209 type sequence G description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 11) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 12) chain A residue 138 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 303 source : AC3 13) chain A residue 246 type sequence R description BINDING SITE FOR RESIDUE SO4 A 303 source : AC3 14) chain A residue 249 type sequence H description BINDING SITE FOR RESIDUE SO4 A 303 source : AC3 15) chain A residue 54 type sequence H description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 16) chain A residue 106 type sequence H description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 17) chain A residue 205 type sequence D description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 18) chain A residue 206 type sequence S description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 19) chain A residue 208 type sequence Q description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 20) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 21) chain A residue 231 type sequence W description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 22) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 23) chain A residue 242 type sequence G description BINDING SITE FOR RESIDUE 675 A 1001 source : AC4 24) chain A residue 157 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:9151681 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 50-55 type prosite sequence ISATHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC source prosite : PS00134 26) chain A residue 205-216 type prosite sequence DSCQGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV source prosite : PS00135 27) chain A residue 156 type CARBOHYD sequence Q description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI3 28) chain A residue 54 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 29) chain A residue 109 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 30) chain A residue 211 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1

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