eF-site ID 1ov4-A PDB Code 1ov4 Chain A click to enlarge Title Crystal structure of human DHEA-ST complexed with androsterone Classification TRANSFERASE Compound Alcohol sulfotransferase Source Homo sapiens (Human) (ST2A1_HUMAN) Sequence A:  SDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILT YPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESE IGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMR NPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYG SWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQF LGKTLEPEELNLILKNSSFQSMKEYVVDKTQLSGDWKNHF TVAQAEDFDKLFQEKMADLPRELFPWE Description Functional site 1) chain A residue 44 type sequence K description BINDING SITE FOR RESIDUE SO4 A 286 source : AC1 2) chain A residue 45 type sequence S description BINDING SITE FOR RESIDUE SO4 A 286 source : AC1 3) chain A residue 46 type sequence G description BINDING SITE FOR RESIDUE SO4 A 286 source : AC1 4) chain A residue 47 type sequence T description BINDING SITE FOR RESIDUE SO4 A 286 source : AC1 5) chain A residue 48 type sequence N description BINDING SITE FOR RESIDUE SO4 A 286 source : AC1 6) chain A residue 18 type sequence F description BINDING SITE FOR RESIDUE AOX A 287 source : AC2 7) chain A residue 72 type sequence W description BINDING SITE FOR RESIDUE AOX A 287 source : AC2 8) chain A residue 80 type sequence S description BINDING SITE FOR RESIDUE AOX A 287 source : AC2 9) chain A residue 99 type sequence H description BINDING SITE FOR RESIDUE AOX A 287 source : AC2 10) chain A residue 133 type sequence F description BINDING SITE FOR RESIDUE AOX A 287 source : AC2 11) chain A residue 134 type sequence W description BINDING SITE FOR RESIDUE AOX A 287 source : AC2 12) chain A residue 100 type ACT_SITE sequence L description Proton acceptor => ECO:0000269|PubMed:11988089, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1J99, ECO:0007744|PDB:1OV4 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 45 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 14) chain A residue 47 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 15) chain A residue 49 type BINDING sequence W description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 16) chain A residue 46 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 17) chain A residue 48 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 18) chain A residue 50 type BINDING sequence L description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 19) chain A residue 122 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 20) chain A residue 130 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 21) chain A residue 219 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 22) chain A residue 185 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI4 23) chain A residue 224 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI5 24) chain A residue 252 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6

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