eF-site ID 1osv-A PDB Code 1osv Chain A click to enlarge Title STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR Classification DNA BINDING PROTEIN Compound Bile acid receptor Source Rattus norvegicus (Rat) (NCOA2_MOUSE) Sequence A:  AELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFSAEE NFLILTEMATSHVQILVEFTKRLPGFQTLDHEDQIALLKG SAVEAMFLRSAEIFNKKLPAGHADLLEERIRKSGISDEYI TPMFSFYKSVGELKMTQEEYALLTAIVILSPDRQYIKDRE AVEKLQEPLLDVLQKLCKIYQPENPQHFACLLGRLTELRT FNHHHAEMLMSWRVNDHKFTPLLCEIWDV Description Functional site 1) chain A residue 262 type sequence M description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 2) chain A residue 325 type sequence M description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 3) chain A residue 326 type sequence F description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 4) chain A residue 328 type sequence R description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 5) chain A residue 329 type sequence S description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 6) chain A residue 349 type sequence I description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 7) chain A residue 358 type sequence Y description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 8) chain A residue 362 type sequence M description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 9) chain A residue 366 type sequence Y description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 10) chain A residue 444 type sequence H description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 11) chain A residue 466 type sequence W description BINDING SITE FOR RESIDUE CHC A 202 source : AC2 12) chain A residue 328 type BINDING sequence R description BINDING => ECO:0000305|PubMed:12718893, ECO:0007744|PDB:1OSV, ECO:0007744|PDB:1OT7 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 358 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:12718893, ECO:0007744|PDB:1OSV, ECO:0007744|PDB:1OT7 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 366 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:12718893, ECO:0007744|PDB:1OSV, ECO:0007744|PDB:1OT7 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 444 type BINDING sequence H description BINDING => ECO:0000305|PubMed:12718893, ECO:0007744|PDB:1OSV source Swiss-Prot : SWS_FT_FI2 16) chain A residue 439 type MOD_RES sequence T description Phosphothreonine; by PKC/PRKCZ => ECO:0000250|UniProtKB:Q96RI1 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 272 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000250|UniProtKB:Q96RI1 source Swiss-Prot : SWS_FT_FI4

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