|
|
eF-site ID
|
1osj-A |
|
PDB Code
|
1osj |
|
Chain
|
A |
|
click to enlarge
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Title
|
STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE |
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Classification
|
OXIDOREDUCTASE |
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Compound
|
3-ISOPROPYLMALATE DEHYDROGENASE |
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Source
|
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (Q5SIY4_THET8) |
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Sequence
|
A: |
MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFP
FGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGL
PRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKE
EIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKP
EVERVARVAFELARKRRKHVVSVDKANVLEVGEFWRKTVE
EVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFG
DILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIA
GKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALL
ETPPPDLGGSAGTEAFTATVLRHLA
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
74 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:7881901
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
274 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:7881901
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
139 |
| type |
SITE |
| sequence |
Y
|
| description |
Important for catalysis
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
A |
| residue |
185 |
| type |
SITE |
| sequence |
K
|
| description |
Important for catalysis => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
5)
|
chain |
A |
| residue |
94 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
104 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
132 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
217 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
241 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
A |
| residue |
245 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
11)
|
chain |
A |
| residue |
237-256 |
| type |
prosite |
| sequence |
NIFGDILSDLASVLPGSLGL
|
| description |
IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NIFGDIlSDlaSvlp.GSLGL
|
| source |
prosite : PS00470
|
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|