eF-site ID 1oky-A
PDB Code 1oky
Chain A

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Title Structure of human PDK1 kinase domain in complex with staurosporine
Classification TRANSFERASE
Compound 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1
Source (PDPK_HUMAN)
Sequence A:  PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIK
ILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQD
DEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS
ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS
PANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVA
GLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLL
VLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK
LTA
Description


Functional site

1) chain A
residue 76
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A1363
source : AC1

2) chain A
residue 131
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1363
source : AC1

3) chain A
residue 148
type
sequence T
description BINDING SITE FOR RESIDUE SO4 A1363
source : AC1

4) chain A
residue 149
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A1363
source : AC1

5) chain A
residue 150
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A1363
source : AC1

6) chain A
residue 75
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1364
source : AC2

7) chain A
residue 136
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1364
source : AC2

8) chain A
residue 199
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A1364
source : AC2

9) chain A
residue 106
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1365
source : AC3

10) chain A
residue 351
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A1365
source : AC3

11) chain A
residue 83
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A1366
source : AC4

12) chain A
residue 84
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A1366
source : AC4

13) chain A
residue 194
type
sequence E
description BINDING SITE FOR RESIDUE SO4 A1366
source : AC4

14) chain A
residue 334
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A1366
source : AC4

15) chain A
residue 100
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1367
source : AC5

16) chain A
residue 88
type
sequence L
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

17) chain A
residue 89
type
sequence G
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

18) chain A
residue 96
type
sequence V
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

19) chain A
residue 109
type
sequence A
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

20) chain A
residue 111
type
sequence K
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

21) chain A
residue 160
type
sequence S
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

22) chain A
residue 161
type
sequence Y
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

23) chain A
residue 162
type
sequence A
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

24) chain A
residue 165
type
sequence G
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

25) chain A
residue 166
type
sequence E
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

26) chain A
residue 209
type
sequence E
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

27) chain A
residue 212
type
sequence L
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

28) chain A
residue 222
type
sequence T
description BINDING SITE FOR RESIDUE STU A1368
source : AC6

29) chain A
residue 106
type
sequence R
description BINDING SITE FOR RESIDUE GOL A1360
source : AC7

30) chain A
residue 107
type
sequence E
description BINDING SITE FOR RESIDUE GOL A1360
source : AC7

31) chain A
residue 108
type
sequence Y
description BINDING SITE FOR RESIDUE GOL A1360
source : AC7

32) chain A
residue 160
type
sequence S
description BINDING SITE FOR RESIDUE GOL A1360
source : AC7

33) chain A
residue 161
type
sequence Y
description BINDING SITE FOR RESIDUE GOL A1360
source : AC7

34) chain A
residue 106
type
sequence R
description BINDING SITE FOR RESIDUE GOL A1361
source : AC8

35) chain A
residue 107
type
sequence E
description BINDING SITE FOR RESIDUE GOL A1361
source : AC8

36) chain A
residue 351
type
sequence H
description BINDING SITE FOR RESIDUE GOL A1361
source : AC8

37) chain A
residue 352
type
sequence Q
description BINDING SITE FOR RESIDUE GOL A1361
source : AC8

38) chain A
residue 103
type
sequence A
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

39) chain A
residue 104
type
sequence T
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

40) chain A
residue 105
type
sequence S
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

41) chain A
residue 139
type
sequence H
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

42) chain A
residue 191
type
sequence S
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

43) chain A
residue 347
type
sequence W
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

44) chain A
residue 349
type
sequence N
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

45) chain A
residue 350
type
sequence L
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

46) chain A
residue 351
type
sequence H
description BINDING SITE FOR RESIDUE GOL A1362
source : AC9

47) chain A
residue 241
type MOD_RES
sequence X
description Phosphoserine; by autocatalysis => ECO:0000269|PubMed:10455013, ECO:0000269|PubMed:11481331, ECO:0000269|PubMed:15772071, ECO:0000269|PubMed:16780920, ECO:0000269|Ref.8
source Swiss-Prot : SWS_FT_FI4

48) chain A
residue 304
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:Q9Z2A0
source Swiss-Prot : SWS_FT_FI5

49) chain A
residue 354
type MOD_RES
sequence T
description Phosphothreonine; by MELK => ECO:0000269|PubMed:22544756
source Swiss-Prot : SWS_FT_FI6

50) chain A
residue 88-111
type prosite
sequence LGEGSFSTVVLARELATSREYAIK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGSFSTVVlArelatsre..........YAIK
source prosite : PS00107

51) chain A
residue 201-213
type prosite
sequence IIHRDLKPENILL
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpeNILL
source prosite : PS00108

52) chain A
residue 205
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

53) chain A
residue 92
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:12169624, ECO:0000269|PubMed:15741170, ECO:0000269|PubMed:22999883
source Swiss-Prot : SWS_FT_FI2

54) chain A
residue 111
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:12169624, ECO:0000269|PubMed:15741170, ECO:0000269|PubMed:22999883
source Swiss-Prot : SWS_FT_FI2

55) chain A
residue 160
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:12169624, ECO:0000269|PubMed:15741170, ECO:0000269|PubMed:22999883
source Swiss-Prot : SWS_FT_FI2

56) chain A
residue 166
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:12169624, ECO:0000269|PubMed:15741170, ECO:0000269|PubMed:22999883
source Swiss-Prot : SWS_FT_FI2

57) chain A
residue 223
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:12169624, ECO:0000269|PubMed:15741170, ECO:0000269|PubMed:22999883
source Swiss-Prot : SWS_FT_FI2

58) chain A
residue 209
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:22999883
source Swiss-Prot : SWS_FT_FI3


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