eF-site ID 1ogk-ABDE PDB Code 1ogk Chain A, B, D, E click to enlarge Title The crystal structure of Trypanosoma cruzi dUTPase in complex with dUDP Classification HYDROLASE Compound DEOXYURIDINE TRIPHOSPHATASE Source Trypanosoma cruzi (O15923_TRYCR) Sequence A:  VPARVLNSLAHLQDGLNIFMDPDWRQIRHVDDWALAITME SAELIDSYPWKWWKNVKAQTDMHNVRIEIADILHFSLSGE IQKRDDVALKSLKEMGFFCRPPADDELLELMFFPLTEVAS AVATFRNIIQLASIYRFDLITKGLLLAAQDLDFNLVGYYV AKYTLNQIRQLEDNELLHECVQSVSVEDVLNEGTYLKAWE KIACSVFDAFGMPEEERRHAYDWLKSAALD B:  PARVLNSLAHLQDGLNIFMDPDWRQIRHVDDWALAITMES AELIDSYPWKWWKNVKAQTDMHNVRIEIADILHFSLSGEI QKRDVALKSLKEMGFFCRPPDELLELMFFPLTEVASAVAT FRNIIQLASIYRFDLITKGLLLAAQDLDFNLVGYYVAKYT LNQIRQLKGYKEGVYVKVREGVEDNELLHECVQSVSVEDV LNEGTYLKAWEKIACSVFDAFGMPEEERRHAYDWLKSAAL D:  PARVLNSLAHLQDGLNIFMDPDWRQIRHVDDWALAITMES AELIDSYPWKWWKNVKAQTDMHNVRIEIADILHFSLSGEI QKRALKSLKEMGFFCRPPDELLELMFFPLTEVASAVATFR NIIQLASIYRFDLITKGLLLAAQDLDFNLVGYYVAKYTLN QIRQLKGYKEGVYVKVREGVEDNELLHECVQSVSVEDVLN EGTYLKAWEKIACSVFDAFGMPEEERRHAYDWLKSAAL E:  VPARVLNSLAHLQDGLNIFMDPDWRQIRHVDDWALAITME SAELIDSYPWKWWKNVKAQTDMHNVRIEIADILHFSLSGE IQKRDVALKSLKEMGFFCRPPDELLELMFFPLTEVASAVA TFRNIIQLASIYRFDLITKGLLLAAQDLDFNLVGYYVAKY TLNQIRQLKGYKEGVYVKVREGVEDNELLHECVQSVSVED VLNEGTYLKAWEKIACSVFDAFGMPEEERRHAYDWLKSAA LD Description Functional site 1) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 2) chain A residue 61 type sequence W description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 3) chain A residue 62 type sequence W description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 4) chain B residue 22 type sequence Q description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 5) chain B residue 25 type sequence L description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 6) chain B residue 26 type sequence N description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 7) chain B residue 29 type sequence M description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 8) chain B residue 42 type sequence W description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 9) chain B residue 49 type sequence E description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 10) chain B residue 52 type sequence E description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 11) chain B residue 77 type sequence E description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 12) chain B residue 80 type sequence D description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 13) chain B residue 83 type sequence H description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 14) chain B residue 84 type sequence F description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 15) chain B residue 197 type sequence K description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 16) chain B residue 201 type sequence N description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 17) chain B residue 204 type sequence R description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 18) chain B residue 209 type sequence Y description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 19) chain B residue 216 type sequence K description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 20) chain B residue 224 type sequence N description BINDING SITE FOR RESIDUE DUD B1280 source : AC1 21) chain D residue 22 type sequence Q description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 22) chain D residue 25 type sequence L description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 23) chain D residue 26 type sequence N description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 24) chain D residue 29 type sequence M description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 25) chain D residue 42 type sequence W description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 26) chain D residue 49 type sequence E description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 27) chain D residue 52 type sequence E description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 28) chain D residue 80 type sequence D description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 29) chain D residue 83 type sequence H description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 30) chain D residue 84 type sequence F description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 31) chain D residue 197 type sequence K description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 32) chain D residue 201 type sequence N description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 33) chain D residue 204 type sequence R description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 34) chain D residue 209 type sequence Y description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 35) chain D residue 216 type sequence K description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 36) chain D residue 224 type sequence N description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 37) chain E residue 60 type sequence K description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 38) chain E residue 61 type sequence W description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 39) chain E residue 62 type sequence W description BINDING SITE FOR RESIDUE DUD D1280 source : AC2 40) chain D residue 60 type sequence K description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 41) chain D residue 61 type sequence W description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 42) chain D residue 62 type sequence W description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 43) chain E residue 22 type sequence Q description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 44) chain E residue 25 type sequence L description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 45) chain E residue 26 type sequence N description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 46) chain E residue 42 type sequence W description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 47) chain E residue 49 type sequence E description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 48) chain E residue 52 type sequence E description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 49) chain E residue 77 type sequence E description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 50) chain E residue 80 type sequence D description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 51) chain E residue 83 type sequence H description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 52) chain E residue 84 type sequence F description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 53) chain E residue 197 type sequence K description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 54) chain E residue 201 type sequence N description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 55) chain E residue 204 type sequence R description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 56) chain E residue 209 type sequence Y description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 57) chain E residue 216 type sequence K description BINDING SITE FOR RESIDUE DUD E1281 source : AC3 58) chain E residue 224 type sequence N description BINDING SITE FOR RESIDUE DUD E1281 source : AC3

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