eF-site ID 1ofn-AB PDB Code 1ofn Chain A, B click to enlarge Title Purification, crystallisation and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis; the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway. Classification ISOMERASE Compound PCZA361.16 Source (O52806) Sequence A:  MQARKLAVDGAIEFTPRVFADDRGLLILPYQEEAFVEAHG GPLFRVAQTIHSMSKRGVVRGIHYTVTPPGTAKYVYCARG KAMDIVIDIRVGSPTFGQWDSVLMDQQDPRAVYLPVGVGH AFVALEDDTVMSYMLSRSYVTQDELALSALDPALGLPIDI GVEPIVSDRDRVAITLAEAQRQGLLPDYTTSQEIERRLTA VP B:  MQARKLAVDGAIEFTPRVFADDRGLLILPYQEEAFVEAHG GPLFRVAQTIHSMSKRGVVRGIHYTVTPPGTAKYVYCARG KAMDIVIDIRVGSPTFGQWDSVLMDQQDPRAVYLPVGVGH AFVALEDDTVMSYMLSRSYVTQDELALSALDPALGLPIDI GVEPIVSDRDRVAITLAEAQRQGLLPDYTTSQEIERRLTA VPV Description Functional site 1) chain A residue 19 type sequence F description BINDING SITE FOR RESIDUE GOL A1203 source : AC1 2) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE GOL A1203 source : AC1 3) chain A residue 23 type sequence R description BINDING SITE FOR RESIDUE GOL A1203 source : AC1 4) chain A residue 24 type sequence G description BINDING SITE FOR RESIDUE GOL A1203 source : AC1 5) chain A residue 25 type sequence L description BINDING SITE FOR RESIDUE GOL A1203 source : AC1 6) chain A residue 26 type sequence L description BINDING SITE FOR RESIDUE GOL A1203 source : AC1 7) chain B residue 60 type sequence R description BINDING SITE FOR RESIDUE GOL A1203 source : AC1 8) chain A residue 49 type sequence T description BINDING SITE FOR RESIDUE GOL A1204 source : AC2 9) chain A residue 132 type sequence S description BINDING SITE FOR RESIDUE GOL A1204 source : AC2 10) chain A residue 134 type sequence M description BINDING SITE FOR RESIDUE GOL A1204 source : AC2 11) chain B residue 76 type sequence Y description BINDING SITE FOR RESIDUE GOL A1204 source : AC2 12) chain B residue 132 type sequence S description BINDING SITE FOR RESIDUE GOL A1204 source : AC2 13) chain B residue 134 type sequence M description BINDING SITE FOR RESIDUE GOL A1204 source : AC2 14) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE GOL B1203 source : AC4 15) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE GOL B1203 source : AC4 16) chain B residue 73 type sequence K description BINDING SITE FOR RESIDUE GOL B1203 source : AC4 17) chain B residue 120 type sequence H description BINDING SITE FOR RESIDUE GOL B1203 source : AC4 18) chain B residue 133 type sequence Y description BINDING SITE FOR RESIDUE GOL B1203 source : AC4

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