eF-site ID 1oco-N PDB Code 1oco Chain N click to enlarge Title BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Classification OXIDOREDUCTASE Compound CYTOCHROME C OXIDASE Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; Sequence N:  MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAE LGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGN WLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEA GAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLP VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSI GFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKV FSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLAN SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLF SGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRY SDYPDAYTMWNTISSMGSFISLTAVMLMVFIIWEAFASKR EVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK Description (1)  CYTOCHROME C OXIDASE, HEME-A, CARBON MONOXIDE Functional site 1) chain N residue 240 type sequence H description BINDING SITE FOR RESIDUE CU N 517 source : AC7 2) chain N residue 290 type sequence H description BINDING SITE FOR RESIDUE CU N 517 source : AC7 3) chain N residue 291 type sequence H description BINDING SITE FOR RESIDUE CU N 517 source : AC7 4) chain N residue 368 type sequence H description BINDING SITE FOR RESIDUE MG N 518 source : AC8 5) chain N residue 369 type sequence D description BINDING SITE FOR RESIDUE MG N 518 source : AC8 6) chain N residue 40 type sequence E description BINDING SITE FOR RESIDUE NA N 519 source : AC9 7) chain N residue 43 type sequence Q description BINDING SITE FOR RESIDUE NA N 519 source : AC9 8) chain N residue 45 type sequence G description BINDING SITE FOR RESIDUE NA N 519 source : AC9 9) chain N residue 441 type sequence S description BINDING SITE FOR RESIDUE NA N 519 source : AC9 10) chain N residue 27 type sequence G description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 11) chain N residue 34 type sequence S description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 12) chain N residue 37 type sequence I description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 13) chain N residue 38 type sequence R description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 14) chain N residue 54 type sequence Y description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 15) chain N residue 61 type sequence H description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 16) chain N residue 62 type sequence A description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 17) chain N residue 65 type sequence M description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 18) chain N residue 70 type sequence V description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 19) chain N residue 125 type sequence G description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 20) chain N residue 126 type sequence W description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 21) chain N residue 371 type sequence Y description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 22) chain N residue 377 type sequence F description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 23) chain N residue 378 type sequence H description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 24) chain N residue 381 type sequence L description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 25) chain N residue 382 type sequence S description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 26) chain N residue 390 type sequence M description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 27) chain N residue 425 type sequence F description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 28) chain N residue 428 type sequence Q description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 29) chain N residue 438 type sequence R description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 30) chain N residue 439 type sequence R description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 31) chain N residue 440 type sequence Y description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 32) chain N residue 468 type sequence M description BINDING SITE FOR RESIDUE HEA N 515 source : BC7 33) chain N residue 126 type sequence W description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 34) chain N residue 243 type sequence V description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 35) chain N residue 244 type sequence Y description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 36) chain N residue 290 type sequence H description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 37) chain N residue 291 type sequence H description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 38) chain N residue 309 type sequence T description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 39) chain N residue 312 type sequence I description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 40) chain N residue 316 type sequence T description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 41) chain N residue 317 type sequence G description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 42) chain N residue 352 type sequence G description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 43) chain N residue 355 type sequence G description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 44) chain N residue 356 type sequence I description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 45) chain N residue 358 type sequence L description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 46) chain N residue 359 type sequence A description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 47) chain N residue 364 type sequence D description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 48) chain N residue 368 type sequence H description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 49) chain N residue 376 type sequence H description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 50) chain N residue 377 type sequence F description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 51) chain N residue 380 type sequence V description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 52) chain N residue 381 type sequence L description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 53) chain N residue 438 type sequence R description BINDING SITE FOR RESIDUE HEA N 516 source : BC8 54) chain N residue 240 type sequence H description BINDING SITE FOR RESIDUE CMO N 520 source : BC9 55) chain N residue 243 type sequence V description BINDING SITE FOR RESIDUE CMO N 520 source : BC9 56) chain N residue 291 type sequence H description BINDING SITE FOR RESIDUE CMO N 520 source : BC9 57) chain N residue 61 type catalytic sequence H description 124 source MCSA : MCSA2 58) chain N residue 290 type catalytic sequence H description 124 source MCSA : MCSA2 59) chain N residue 291 type catalytic sequence H description 124 source MCSA : MCSA2 60) chain N residue 316 type catalytic sequence T description 124 source MCSA : MCSA2 61) chain N residue 319 type catalytic sequence K description 124 source MCSA : MCSA2 62) chain N residue 438 type catalytic sequence R description 124 source MCSA : MCSA2 63) chain N residue 91 type catalytic sequence D description 124 source MCSA : MCSA2 64) chain N residue 126 type catalytic sequence W description 124 source MCSA : MCSA2 65) chain N residue 156 type catalytic sequence S description 124 source MCSA : MCSA2 66) chain N residue 157 type catalytic sequence S description 124 source MCSA : MCSA2 67) chain N residue 240 type catalytic sequence H description 124 source MCSA : MCSA2 68) chain N residue 242 type catalytic sequence E description 124 source MCSA : MCSA2 69) chain N residue 244 type catalytic sequence Y description 124 source MCSA : MCSA2 70) chain N residue 255 type catalytic sequence S description 124 source MCSA : MCSA2 71) chain N residue 262-269 type TOPO_DOM sequence SGKKEPFG description Mitochondrial matrix => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI1 72) chain N residue 401-406 type TOPO_DOM sequence SGYTLN description Mitochondrial matrix => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI1 73) chain N residue 479-514 type TOPO_DOM sequence KREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK description Mitochondrial matrix => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI1 74) chain N residue 171-182 type TOPO_DOM sequence MKPPAMSQYQTP description Mitochondrial matrix => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI1 75) chain N residue 270-286 type TRANSMEM sequence YMGMVWAMMSIGFLGFI description Helical; Name=VII => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI10 76) chain N residue 299-327 type TRANSMEM sequence VDTRAYFTSATMIIAIPTGVKVFSWLATL description Helical; Name=VIII => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI11 77) chain N residue 328-335 type TOPO_DOM sequence HGGNIKWS description Mitochondrial matrix => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI12 78) chain N residue 336-357 type TRANSMEM sequence PAMMWALGFIFLFTVGGLTGIV description Helical; Name=IX => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI13 79) chain N residue 358-370 type TOPO_DOM sequence LANSSLDIVLHDT description Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI14 80) chain N residue 434-446 type TOPO_DOM sequence SGMPRRYSDYPDA description Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI14 81) chain N residue 371-400 type TRANSMEM sequence YYVVAHFHYVLSMGAVFAIMGGFVHWFPLF description Helical; Name=X => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI15 82) chain N residue 407-433 type TRANSMEM sequence DTWAKIHFAIMFVGVNMTFFPQHFLGL description Helical; Name=XI => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI16 83) chain N residue 447-478 type TRANSMEM sequence YTMWNTISSMGSFISLTAVMLMVFIIWEAFAS description Helical; Name=XII => ECO:0000269|PubMed:27605664 source Swiss-Prot : SWS_FT_FI17 84) chain N residue 40 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 source Swiss-Prot : SWS_FT_FI18 85) chain N residue 45 type BINDING sequence G description BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 source Swiss-Prot : SWS_FT_FI18 86) chain N residue 441 type BINDING sequence S description BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 source Swiss-Prot : SWS_FT_FI18 87) chain N residue 61 type BINDING sequence H description axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI19 88) chain N residue 376 type BINDING sequence H description axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI19 89) chain N residue 378 type BINDING sequence H description axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI19 90) chain N residue 369 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI20 91) chain N residue 240 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI20 92) chain N residue 290 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI20 93) chain N residue 291 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI20 94) chain N residue 368 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 source Swiss-Prot : SWS_FT_FI20 95) chain N residue 244 type BINDING sequence Y description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI21 96) chain N residue 1 type MOD_RES sequence M description N-formylmethionine => ECO:0000269|PubMed:2165784 source Swiss-Prot : SWS_FT_FI22 97) chain N residue 240 type CROSSLNK sequence H description 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009 source Swiss-Prot : SWS_FT_FI23 98) chain N residue 244 type CROSSLNK sequence Y description 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009 source Swiss-Prot : SWS_FT_FI23 99) chain N residue 213-227 type MOD_RES sequence RNLNTTFFDPAGGGD description Phosphoserine => ECO:0000250|UniProtKB:P10888 source Swiss-Prot : SWS_FT_FI6 100) chain N residue 287-298 type MOD_RES sequence VWAHHMFTVGMD description Phosphoserine => ECO:0000250|UniProtKB:P10888 source Swiss-Prot : SWS_FT_FI6

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