|
|
eF-site ID
|
1o9s-K |
|
PDB Code
|
1o9s |
|
Chain
|
K |
|
click to enlarge
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Title
|
Crystal structure of a ternary complex of the human histone methyltransferase SET7/9 |
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Classification
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TRANSFERASE |
|
Compound
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HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC |
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Source
|
Homo sapiens (Human) (Q16776) |
|
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Sequence
|
K: |
ARTXQTARKY
|
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Description
|
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Functional site
|
|
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1)
|
chain |
K |
| residue |
4 |
| type |
|
| sequence |
X
|
| description |
BINDING SITE FOR RESIDUE SAH A1367
|
| source |
: AC1
|
|
|
2)
|
chain |
K |
| residue |
5 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
3)
|
chain |
K |
| residue |
6 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
4)
|
chain |
K |
| residue |
8 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
5)
|
chain |
K |
| residue |
2 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Citrulline; alternate => ECO:0000269|PubMed:16567635
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
K |
| residue |
3 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
K |
| residue |
4 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
8)
|
chain |
K |
| residue |
10 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
9)
|
chain |
K |
| residue |
9 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
|
| source |
Swiss-Prot : SWS_FT_FI7
|
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